Synthesis, docking studies, and biological evaluation of 1, 2, 4-triazole-linked quinoxaline derivatives

3-(5-Mercapto-4-amino-1, 2, 4-triazol-3-yl) quinoxalin-2-ols were obtained from diethy 2-bromomalonate and o-phenylenediamine through multistep reactions. Ethyl 3-hydroxyquinoxaline-2-carboxylate on hydrazinolysis with substituted hydrazines resulted into 3-hydroxyquinoxaline-2-carbohydrazides (3a-g) which on reaction with CS2/KOH gave potassium 2-(3-hydroxyquinoxaline-2-carbonyl)hydrazine carbothioates (4a-g). Potassium 2-(3-hydroxyquinoxaline-2-carbonyl)hydrazine carbothioate (4a) on cyclization with substituted hydrazines gave 3-(5-mercapto-4-amino-1,2,4-triazol-3-yl)quinoxalin-2-ols (5a-g).The compounds were characterized by spectral analysis CH nuclear magnetic resonance [NMR], C-13 NMR, and mass spectrometry). Docking results are also presented for compounds 5a-g. [GRAPHICS] .