Total synthesis and absolute stereochemistry of polygalolides A and B

被引：58
|
作者：
Nakamura, Seiichi [1 ]
Sugano, Yukihito [1 ]
Kikuchi, Fumiaki [1 ]
Hashimoto, Shunichi [1 ]
机构：
[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 39期
关键词：
aldol reaction; carbonyl ylides; cycloaddition; diazo compounds; total synthesis;
D O I：
10.1002/anie.200602030
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Carbonyl ylides to the fore: the first total synthesis of polygalolides A (1) and B (2) has been achieved by exploiting a tandem carbonyl ylide formation/1,3-dipolar cycloaddition to construct the unprecedented 5,10-dioxatricyclo-[6.2.1.0]undecane core structure of these molecules in a single step. © 2006 Wiley-VCH Verlag GmbH &. Co. KGaA.
引用
收藏
页码：6532 / 6535
页数：4
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