Prognostic and predictive response factors in colorectal cancer patients: Between hope and reality

被引:86
|
作者
De Divitiis, Chiara [1 ]
Nasti, Guglielmo [1 ]
Montano, Massimo [1 ]
Fisichella, Rossella [2 ]
Iaffaioli, Rosario Vincenzo [1 ]
Berretta, Massimiliano [3 ,4 ]
机构
[1] Natl Canc Inst G Pascale Fdn, Abdominal Dept, I-80131 Naples, Italy
[2] Univ Catania, Dept Surg, Policlin Univ G Rodolico, I-95123 Catania, Italy
[3] Natl Canc Inst Aviano, Dept Med Oncol, I-33081 Aviano, Italy
[4] Euromediterranean Inst Sci & Technol IEMEST, I-90139 Palermo, Italy
关键词
Colorectal cancer; Prognosis; Prognostic factors; Therapy; Metastases; Molecular analyses; CARBOHYDRATE ANTIGEN 19-9; OXALIPLATIN-BASED CHEMOTHERAPY; ACTIVE ANTIRETROVIRAL THERAPY; ISLAND METHYLATOR PHENOTYPE; HIV-POSITIVE PATIENTS; K-RAS MUTATION; CARCINOEMBRYONIC ANTIGEN; LIVER METASTASES; ELDERLY-PATIENTS; CETUXIMAB PLUS;
D O I
10.3748/wjg.v20.i41.15049
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Colorectal cancer (CRC) represents one of the most commonly diagnosed cancers worldwide. It is the second leading cause of cancer death in Western Countries. In the last decade the survival of patients with metastatic CRC has improved dramatically. Due to the advent of new drugs (irinotecan and oxaliplatin) and target therapies (i.e., bevacizumab, cetuximab and panitumab), the median overall survival has risen from about 12 mo in the mid nineties to 30 mo recently. Many questions needing of right collocations and more clearness still exist regarding the prognostic factors and the predictive factors of response to therapy. Despite advances in dosing and scheduling of chemotherapy in both adjuvant and advanced settings, and a greater emphasis on early detection, the outlook still remains poor for most patients. Molecular analyses have shown that the natural history of all CRCs is not the same. Individual patients with same stage tumours may have different long term prognosis and response to therapy. In addition, some prognostic variables are likely to be more important than others. Here we review the role of prognostic factors and predictive factors according to the recently published English literature. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
引用
收藏
页码:15049 / 15059
页数:11
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