Alterations in circulating angiogenic and anti-angiogenic factors in type 2 diabetic patients with neuropathy

被引:24
|
作者
Motawi, Tarek Kamal [1 ]
Rizk, Sherine Maher [1 ]
Ibrahim, Ihab Abdel-Rahman [2 ]
El-Emady, Yasmin Farid [3 ]
机构
[1] Cairo Univ, Fac Pharm, Cairo, Egypt
[2] Cairo Univ, Fac Med, Cairo, Egypt
[3] Holding Co Biol Prod & Vaccines, Cairo, Egypt
关键词
vascular endothelial growth factor; soluble endoglin; endothelin-1; mRNA; nitric oxide; diabetic peripheral neuropathy; ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE; OXIDATIVE STRESS; GLYCEMIC CONTROL; PERIPHERAL NEUROPATHY; PLASMA ENDOTHELIN; FACTOR EXPRESSION; SOLUBLE ENDOGLIN; GENE-EXPRESSION; HIGH GLUCOSE;
D O I
10.1002/cbf.2987
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diabetic peripheral neuropathy (DPN) is one of the most common diabetic chronic complications. There is an increased attention directed towards the role of angiogenic factors including vascular endothelial growth factor (VEGF) and anti-angiogenic factors including soluble endoglin (sEng) as contributors to diabetic microvascular complications including neuropathy. The purposes of this study were to determine the role of these angiogenesis regulators in the prognosis of DPN. The study group included 60 patients with type 2 diabetes mellitus (T2DM) and 20 clinically healthy individuals. The patients were divided into two groups. Group I included 20 T2DM patients without peripheral neuropathy, and Group II consisted of 40 T2DM patients with DPN. In all groups, plasma VEGF, sEng and endothelin-1 (ET-1), nitric oxide and ET-1 mRNA were estimated. Plasma levels of VEGF, sEng, ET-1 and nitric oxide were significantly elevated in diabetic patients (Groups I and II) compared with healthy control subjects, with a higher increase in their levels in patients with DPN compared with diabetic patients without peripheral neuropathy. Measurement of plasma levels of angiogenesis-related biomarkers in high-risk diabetic patients might identify who later develop DPN, thus providing opportunities for early detection and targets for novel treatments. Copyright (c) 2013 John Wiley & Sons, Ltd.
引用
收藏
页码:155 / 163
页数:9
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