Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.

被引：60
|
作者：
He, Yi [1 ,2 ,3 ]
Wang, Bin [4 ]
Chen, Wanping [5 ]
Cox, Russell J. [6 ]
He, Jingren [1 ,2 ,3 ]
Chen, Fusheng [5 ]
机构：
[1] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China
[2] Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China
[3] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China
[4] Shihezi Univ, Food Coll, Xinjiang 832000, Uygur Autonomou, Peoples R China
[5] Huazhong Agr Univ, Coll Food Sci & Technol, Key Lab Environm Correlat Dietol, Wuhan 430070, Hubei, Peoples R China
[6] Leibniz Univ Hannover, BMWZ, Inst Organ Chem, Schneiderberg 1B, D-30167 Hannover, Germany
来源：
BIOTECHNOLOGY ADVANCES | 2018年 / 36卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Heterologous expression; Microbial secondary metabolites; Aspergillus spp; DNA assembly; Combinatorial biosynthesis; Pathway engineering; POLYKETIDE SYNTHASE GENE; HETEROLOGOUS PROTEIN EXPRESSION; 6-METHYLSALICYLIC ACID SYNTHASE; GENOME MINING APPROACH; NATURAL-PRODUCT; NONRIBOSOMAL PEPTIDE; COMBINATORIAL BIOSYNTHESIS; FUNGAL POLYKETIDES; FILAMENTOUS FUNGI; SYSTEMS BIOLOGY;
D O I：
10.1016/j.biotechadv.2018.02.001
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
High throughput genome sequencing has revealed a multitude of potential secondary metabolites biosynthetic pathways that remain cryptic. Pathway reconstruction coupled with genetic engineering via heterologous expression enables discovery of novel compounds, elucidation of biosynthetic pathways, and optimization of product yields. Apart from Escherichia coli and yeast, fungi, especially Aspergillus spp., are well known and efficient heterologous hosts. This review summarizes recent advances in heterologous expression of microbial secondary metabolite biosynthesis in Aspergilhis spp. We also discuss the technological challenges and successes in regard to heterologous host selection and DNA assembly behind the reconstruction of microbial secondary metabolite biosynthesis.
引用
收藏
页码：739 / 783
页数：45
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