Can Desensitizing Toothpastes Also Have an Effect on Gingival Inflammation? A Double-Blind, Three-Treatment Crossover Clinical Trial

被引:9
|
作者
Monterubbianesi, Riccardo [1 ]
Sparabombe, Scilla [1 ]
Tosco, Vincenzo [1 ]
Profili, Fabia [1 ]
Mascitti, Marco [1 ]
Hosein, Andrell [2 ]
Putignano, Angelo [1 ]
Orsini, Giovanna [1 ]
机构
[1] Polytech Univ Marche, Dept Clin Sci & Stomatol, Via Tronto 10, I-60126 Ancona, Italy
[2] Polytech Univ Marche, Dept Clin & Mol Sci, Via Tronto 10, I-60126 Ancona, Italy
关键词
desensitizing toothpastes; CSPS; CHA; anti-inflammatory; anti-inflammatory activity; DENTIN HYPERSENSITIVITY; PLAQUE REMOVAL; DENTIFRICE; FLUORIDE; MOUTHRINSE; EFFICACY; PERIODONTITIS; SENSITIVITY; SURFACE; RINSE;
D O I
10.3390/ijerph17238927
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Many desensitizing toothpastes exist commercially; however, few clinical trials have investigated their anti-inflammatory effects. This study aimed to evaluate the anti-inflammatory effect and patient appreciation of two toothpastes containing desensitizing agents: (1) a zinc-carbonate-hydroxyapatite nanoparticle (CHA) and (2) a calcium sodium phosphosilicate bioactive glass (CSPS). Methods: CHA and CSPS were compared with an anti-inflammatory and antibacterial herbal based toothpaste (HB). The aims were accomplished by comparing the following outcomes: (1) the reduction in plaque and bleeding score (Full Mouth Plaque Score (FMPS) and Full Mouth Bleeding Score (FMBS), respectively); (2) the antibacterial activity (AbA) of the toothpaste by saliva samples; (3) the patient appreciation score (Visual Analogue Scale; VAS). Clinical parameters were assessed at baseline and 14 days post-treatment. Results: The final sample consisted of 25 subjects, aged between 20 and 58 years. Although no differences in FMPS were reported (p > 0.05), both desensitizing toothpastes showed an improvement in FMBS. CSPS and HB recorded more AbA compared to CHA (p < 0.05). Moreover, HB resulted in a higher VAS score than both desensitizing toothpastes (p < 0.05). Conclusion: In conclusion, only CSPS displayed a similar anti-inflammatory effect compared to HB. Despite the low VAS score, CSPS could be considered as a valid and effective toothpaste in subjects with both dentin hypersensitivity and inflamed gums, highlighting its utility in clinical practice.
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页码:1 / 9
页数:9
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