Histopathology and ultrastructure of the liver under combined action of narcotics and hepatitis C and B viruses

被引：0
|
作者：
Nepomnyashchikh, GI [1 ]
Tolokonskaya, NP [1 ]
Sakharova, EG [1 ]
Aidagulova, SV [1 ]
Mezentseva, GA [1 ]
Nepomnyashchikh, LM [1 ]
机构：
[1] Russian Acad Med Sci, Inst Reg Pathol & Pathomorphol, Siberian Div, Lab Ultrastruct Bases Pathol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 128卷 / 09期
关键词：
viral hepatitis; opium addiction; liver autopsy; hepatocytes; light and electron microscopy;
D O I：
10.1007/BF02438098
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Liver autopsy material from opioid addicts with viral hepatitis C and C+B showed hepatocyte dystrophy associated with lipid infiltration, hyperplasia of lymphoid tissue, and perivascular fibrosis. Alteration of hepatocytes were most pronounced in patients with hepatitis C+B. Ultrastructure of hepatocytes is characterized by a reduction of protein synthesizing compartment, an increase in volume density of smooth cytoplasmic reticulum, appearance of megamitochondria, and pronounced collagenization of the Disse space.
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页码：963 / 966
页数：4
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