Taylor dispersion in Poiseuille flow in three-dimensional tubes of varying diameter

Diffusion of particles carried by Poiseuille flow of the surrounding solvent in a three-dimensional (3D) tube of varying diameter is considered. We revisit our mapping technique [F. Slanina and P. Kalinay, Phys. Rev. E 100, 032606 (2019)], projecting the corresponding 3D advection-diffusion equation onto the longitudinal coordinate and generating an effective one-dimensional modified Fick-Jacobs (or Smoluchowski) equation. A different scaling of the transverse forces by a small auxiliary parameter epsilon is used here. It results in a recurrence scheme enabling us to derive the corrections of the effective diffusion coefficient and the averaged driving force up to higher orders in epsilon. The new scaling also preserves symmetries of the stationary solution in any order of epsilon. Finally we show that Reguera-Rubi's formula, widely applied for description of diffusion in corrugated tubes, can be systematically corrected by the strength of the flow Q; we give here the first two terms in the form of closed analytic formulas.