Inhibition of γ-radiation induced DNA damage in plasmid pBR322 by TMG, a water-soluble derivative of vitamin E

被引：42

作者：

Rajagopalan, R

Wani, K

Huilgol, NG

Kagiya, TV

Nair, CKK ^{[1
]}

机构：

[1] Bhabha Atom Res Ctr, Div Radiat Biol, Bombay 400085, Maharashtra, India

[2] Nanavati Hosp & MRC, Dept Radiat Oncol, Vile Parle, India

[3] Kinki Res Fdn, Kyoto, Japan

来源：

JOURNAL OF RADIATION RESEARCH | 2002年 / 43卷 / 02期

关键词：

DNA strandbreaks; thymine glycol; radiation protection; tocopherol monoglucoside;

D O I：

10.1269/jrr.43.153

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alpha-tocopherol monoglucoside (TMG), a water-soluble derivative of alpha-tocopherol, has been examined for its ability to protect DNA against radiation-induced strand breaks. Gamma radiation, up to a dose of 6 Gy (dose rate, 0.7 Gy/ minute), induced a dose-dependent increase in single strand breaks (SSBs) in plasmid pBR322 DNA. TMG inhibited the formation of gamma-radiation induced DNA single strand breaks (SSBs) in a concentration-dependent manner; 500 muM of TMG protected the single strand breaks completely. It also protected thymine glycol formation induced by gamma-radiation in a dose-dependent manner, based on an estimation of thymine glycol by HPLC.

引用

页码：153 / 159

页数：7

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