Correlation between change in muscle excursion and collagen content after tendon rupture and delayed repair

被引:7
|
作者
Koh, Il-Hyun [1 ]
Kang, Ho-Jung [1 ]
Oh, Won-Taek [1 ]
Hong, Jung-Jun [1 ]
Choi, Yun-Rak [1 ]
机构
[1] Yonsei Univ, Coll Med, Dept Orthopaed Surg, 50-1 Yonsei ro, Seoul 120752, South Korea
来源
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH | 2017年 / 12卷
基金
新加坡国家研究基金会;
关键词
Collagen subtypes; Muscle excursion; Tendon rupture; Delayed tendon repair; SKELETAL-MUSCLE; FORCE TRANSMISSION; IV; STIFFNESS; LOCATION; INJURY; LENGTH; MODEL; TEARS; AGE;
D O I
10.1186/s13018-017-0518-y
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Background: The objectives of the present study were to compare changes in muscle excursion, total collagen, and collagen subtypes after tenotomy over time and after delayed tendon repair. Methods: Tenotomy on the extensor digitorum tendon of the right second toes of 48 New Zealand White rabbits was performed; toes on the left leg were used as controls. Passive muscle excursion, total collagen content, and type I, III, and IV collagen contents were measured at 1, 2, 4, and 6 weeks after tenotomy. Next, passive muscle excursion and total collagen content were measured at 8 weeks after delayed tendon repair at 1, 2, 4, and 6 weeks after a tenotomy. Results: Passive muscle excursion decreased sequentially over time after tenotomy. Meanwhile, total collagen increased over time. These changes were significant after 4 weeks of injury. Type I collagen significantly increased, type III collagen significantly decreased, and type IV collagen had no significant change over time. Passive muscle excursion was negatively correlated with total collagen and type I collagen after tenotomy at each time point after tenotomy (p < 0.05). After tendon repair, increases in total collagen content after tenotomy were not reversed, despite early repairs at 1 and 2 weeks after tenotomy. Conclusions: Increases in type I collagen were found to be associated with decreased excursion after tendon rupture. The increase in collagen that was observed after tenotomy was not reversed by repair within 8 weeks.
引用
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页数:7
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