Parkinson's disease in the single-cell era

被引：5
|
作者：
Arenas, Ernest [1 ]
机构：
[1] Karolinska Inst, MBB, Mol Neurobiol, Stockholm, Sweden
来源：
NATURE NEUROSCIENCE | 2022年 / 25卷 / 05期
关键词：
D O I：
10.1038/s41593-022-01069-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Degeneration of dopaminergic neurons in the substantia nigra is a pathological hallmark of Parkinson's disease (PD). However, not all dopamine-producing neurons degenerate. Kamath, Abdulraouf et al. find that there are ten transcriptionally defined dopaminergic subpopulations in the human substantia nigra, but only one carries significant PD genetic risk and is vulnerable to neurodegeneration in PD.
引用
收藏
页码：536 / 538
页数：3
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