Gut microbiome changes in Nonalcoholic fatty liver disease & alcoholic liver disease

被引:20
|
作者
Kwong, Eric K. [1 ]
Puri, Puneet [2 ,3 ]
机构
[1] McGuire VA Med Ctr, Dept Microbiol & Immunol, Richmond, VA USA
[2] McGuire VA Med Ctr, Sect Gastroenterol Hepatol & Nutr, Richmond, VA USA
[3] Virginia Commonwealth Univ, Richmond, VA 23249 USA
关键词
Microbiome; nonalcoholic fatty liver disease (NAFLD); alcoholic fatty liver disease; BILE-ACID METABOLISM; INTESTINAL BARRIER; LEAKY GUT; CIRRHOSIS; INJURY; ETHANOL; FIBROSIS; PHOSPHATIDYLCHOLINE; INFLAMMATION; PERMEABILITY;
D O I
10.21037/tgh.2020.02.18
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are some of the most common liver diseases worldwide. The human gut microbiome is dynamic and shifts in bacterial composition have been implicated in many diseases. Studies have shown that there is a shift in bacterial overgrowth favoring pro-inflammatory mediators in patients with advanced disease progression such as cirrhosis. Further investigation demonstrated that the transplantation of gut microbiota from advanced liver disease patients can reproduce severe liver inflammation and injury in mice. Various techniques in manipulating the gut microbiota have been attempted including fecal transplantation and probiotics. This review focuses on the changes in the gut microbiota as well as emerging lines of microbiome work with respect to NAFLD and ALD.
引用
收藏
页数:11
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