Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

被引：40

作者：

Bourjot, Melanie ^{[1
]}

Leyssen, Pieter ^{[2
]}

Neyts, Johan ^{[2
]}

Dumontet, Vincent ^{[3
]}

Litaudon, Marc ^{[3
]}

机构：

[1] UFR Med & Pharmaceut Sci, Epithelial Funct & Dysfunct EA4267, F-25030 Besancon, France

[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

[3] CNRS, Labex CEBA, Gif Res Ctr, ICSN, F-91198 Gif Sur Yvette, France

来源：

MOLECULES | 2014年 / 19卷 / 03期

关键词：

Trigonostemon cherrieri; Euphorbiaceae; chikungunya virus (CHIKV); daphnane diterpenoid orthoester (DDO); DAPHNANE-TYPE DITERPENOIDS;

D O I：

10.3390/molecules19033617

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A-C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC50 = 0.6 +/- 0.1 mu M, SI = 71.7).

引用

页码：3617 / 3627

页数：11

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