Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

被引：40

作者：

Bourjot, Melanie ^{[1
]}

Leyssen, Pieter ^{[2
]}

Neyts, Johan ^{[2
]}

Dumontet, Vincent ^{[3
]}

Litaudon, Marc ^{[3
]}

机构：

[1] UFR Med & Pharmaceut Sci, Epithelial Funct & Dysfunct EA4267, F-25030 Besancon, France

[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

[3] CNRS, Labex CEBA, Gif Res Ctr, ICSN, F-91198 Gif Sur Yvette, France

来源：

MOLECULES | 2014年 / 19卷 / 03期

关键词：

Trigonostemon cherrieri; Euphorbiaceae; chikungunya virus (CHIKV); daphnane diterpenoid orthoester (DDO); DAPHNANE-TYPE DITERPENOIDS;

D O I：

10.3390/molecules19033617

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A-C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC50 = 0.6 +/- 0.1 mu M, SI = 71.7).

引用

页码：3617 / 3627

页数：11

共 50 条

[1] The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication
Policastro, Lucca R.
Dolci, Isabela
Godoy, Andre S.
Silva Junior, Jose V. J.
Ruiz, Uriel E. A.
Santos, Igor A.
Jardim, Ana C. G.
Samby, Kirandeep
Burrows, Jeremy N.
Wells, Timothy N. C.
Gil, Laura H. V. G.
Oliva, Glaucius
Fernandes, Rafaela S.
VIRUSES-BASEL, 2022, 14 (07):
[2] Identification of 6′-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication
Shin, Young Sup
Jarhad, Dnyandev B.
Jang, Min Hwan
Kovacikova, Kristina
Kim, Gyudong
Yoon, Ji-seong
Kim, Hong-Rae
Hyun, Young Eum
Tipnis, Amol S.
Chang, Tong-Shin
van Hemert, Martijn J.
Jeong, Lak Shin
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 187
[3] Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry
Henss, Lisa
Beck, Simon
Weidner, Tatjana
Biedenkopf, Nadine
Sliva, Katja
Weber, Christopher
Becker, Stephan
Schnierle, Barbara S.
VIROLOGY JOURNAL, 2016, 13
[4] Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry
Lisa Henß
Simon Beck
Tatjana Weidner
Nadine Biedenkopf
Katja Sliva
Christopher Weber
Stephan Becker
Barbara S. Schnierle
Virology Journal, 13
[5] Sorivudine: A potent inhibitor of varicella zoster virus replication
Whitley, RJ
ANTIVIRAL CHEMOTHERAPY 4: NEW DIRECTIONS FOR CLINICAL APPLICATION AND RESEARCH, 1996, 394 : 41 - 44
[6] A sialosyl sulfonate as a potent inhibitor of influenza virus replication
Hadhazi, Adam
Pascolutti, Mauro
Bailly, Benjamin
Dyason, Jeffrey C.
Borbas, Aniko
Thomson, Robin J.
von Itzstein, Mark
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 15 (25) : 5249 - 5253
[7] Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication
Remy, Simon
Litaudon, Marc
MOLECULES, 2019, 24 (12):
[8] The natural compound silvestrol is a potent inhibitor of Ebola virus replication
Biedenkopf, Nadine
Lange-Gruenweller, Kerstin
Schulte, Falk W.
Weisser, Aileen
Mueller, Christin
Becker, Dirk
Becker, Stephan
Hartmann, Roland K.
Gruenweller, Arnold
ANTIVIRAL RESEARCH, 2017, 137 : 76 - 81
[9] Nigericin is a potent inhibitor of the early stage of vaccinia virus replication
Myskiw, Chad
Piper, Jessica
Huzarewich, Rhiannon
Booth, Tim F.
Cao, Jingxin
He, Runtao
ANTIVIRAL RESEARCH, 2010, 88 (03) : 304 - 310
[10] Silvestrol Inhibits Chikungunya Virus Replication
Henss, Lisa
Scholz, Tatjana
Gruenweller, Arnold
Schnierle, Barbara S.
VIRUSES-BASEL, 2018, 10 (11):

← 1 2 3 4 5 →