Clopidogrel inhibits shear-induced platelet function

被引：7

作者：

Orford, JL ^{[1
]}

Kinlay, S ^{[1
]}

Adams, MR ^{[1
]}

Simon, DI ^{[1
]}

Selwyn, AP ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Cardiac Catheterizat Lab, Boston, MA 02115 USA

来源：

PLATELETS | 2002年 / 13卷 / 03期

关键词：

D O I：

10.1080/09537100220127579

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We enrolled 17 healthy adult volunteers and measured platelet hemostasis time (PHT) and collagen-induced thrombus formation (CITF) before and after the oral administration of 300 mg of clopidogrel utilizing the Xylum Clot Signature Analyzer(R). We documented a statistically significant 30% prolongation of the PHT from 291+/-13 (SE) seconds to 376+/-31 (SE) s (P=0.037). There was a 7% prolongation of the CITF from 347+/-10 to 371+/- 17 (SE) s (P=0.245). This study suggests that the Xylum Clot Signature Analyzer can measure changes in platelet function in response to a modest platelet inhibitor, and may be a useful clinical tool for the monitoring of antiplatelet therapies in patients.

引用

页码：187 / 189

页数：3

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