Clopidogrel inhibits shear-induced platelet function

被引：7
|
作者：
Orford, JL [1 ]
Kinlay, S [1 ]
Adams, MR [1 ]
Simon, DI [1 ]
Selwyn, AP [1 ]
机构：
[1] Brigham & Womens Hosp, Cardiac Catheterizat Lab, Boston, MA 02115 USA
来源：
PLATELETS | 2002年 / 13卷 / 03期
关键词：
D O I：
10.1080/09537100220127579
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We enrolled 17 healthy adult volunteers and measured platelet hemostasis time (PHT) and collagen-induced thrombus formation (CITF) before and after the oral administration of 300 mg of clopidogrel utilizing the Xylum Clot Signature Analyzer(R). We documented a statistically significant 30% prolongation of the PHT from 291+/-13 (SE) seconds to 376+/-31 (SE) s (P=0.037). There was a 7% prolongation of the CITF from 347+/-10 to 371+/- 17 (SE) s (P=0.245). This study suggests that the Xylum Clot Signature Analyzer can measure changes in platelet function in response to a modest platelet inhibitor, and may be a useful clinical tool for the monitoring of antiplatelet therapies in patients.
引用
收藏
页码：187 / 189
页数：3
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