In vivo activation of PPARα reduces ischemia/reperfusion-induced myocardial infarct and improves contractile dysfunction by inhibition of neutrophil accumulation and matrix metalloproteinase expression

被引:0
|
作者
Yue, TL [1 ]
Bao, WK [1 ]
Brown, PJ [1 ]
Romanic, AM [1 ]
Boyce, RW [1 ]
Gu, JL [1 ]
Burns-Kurtis, CL [1 ]
Mirabile, RC [1 ]
Ohlstein, EH [1 ]
Bril, A [1 ]
机构
[1] GlaxoSmithKline, King Of Prussia, PA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1335
引用
收藏
页码:265 / 266
页数:2
相关论文
共 36 条
  • [31] Activation of G protein-coupled estrogen receptor (GPER/GPR30) ameliorates myocardial ischemia/reperfusion-induced cardiac dysfunction and norepinephrine overflow
    Sawano, Tatsuya
    Tawa, Masashi
    Koyama, Takeshi
    Wada, Tomoyo
    Ohkita, Mamoru
    Matsumura, Yasuo
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124 : 158P - 158P
  • [32] Co-expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia-reperfusion injury by promoting angiogenesis and inhibiting oxidative stress
    Huang, Shujie
    Chen, Meixian
    Yu, Huizhen
    Lin, Kaiyang
    Guo, Yansong
    Zhu, Pengli
    MOLECULAR MEDICINE REPORTS, 2021, 23 (02)
  • [33] miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling
    Wang, Guangzhi
    Yao, Jihong
    Li, Zhenlu
    Zu, Guo
    Feng, Dongcheng
    Shan, Wen
    Li, Yang
    Hu, Yan
    Zhao, Yongfu
    Tian, Xiaofeng
    ANTIOXIDANTS & REDOX SIGNALING, 2016, 24 (17) : 961 - 973
  • [34] Cardioprotection Induced by Nitric Oxide During Ischemia-Reperfusion of Coronary Arteries Is Mediated by Inhibition of Extracellular Matrix Metalloproteinase Inducer EMMPRIN Expression in Mouse Hearts
    Tarin, Carlos
    Gomez, Monica
    Lavin, Begona
    Diez-Juan, Antonio
    Saura, Marta
    Zaragoza, Carlos
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (07) : E100 - E100
  • [35] Myocardial Ischemia-Reperfusion Injury-Induced Mitochondrial and Contractile Dysfunction is Accompanied by De Novo Expression of NTT-MMP-2 and Mitofusin-2 Proteolysis
    Bassiouni, Wesam
    Valencia, Robert
    Mahmud, Zabed
    Seubert, John M.
    Schulz, Richard
    BRITISH JOURNAL OF PHARMACOLOGY, 2023, 180 : 115 - 116
  • [36] Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARγ activation in human gingival fibroblasts
    Stewart, Denise
    Javadi, Masoud
    Chambers, Mariah
    Gunsolly, Chad
    Gorski, Grzegorz
    Borghaei, Ruth C.
    BMC MOLECULAR BIOLOGY, 2007, 8