Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis

被引：68
|
作者：
Thangarajh, M [1 ]
Gomes, A [1 ]
Masterman, T [1 ]
Hillert, J [1 ]
Hjelmström, P [1 ]
机构：
[1] Huddinge Univ Hosp, Karolinska Inst, Neurotec Dept, Div Neurol, SE-14186 Stockholm, Sweden
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 152卷 / 1-2期
关键词：
B lymphocyte; tumor necrosis factor superfamily; autoimmune disorders; multiple sclerosis;
D O I：
10.1016/j.jneuroim.2004.03.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of B cells and antibodies in the pathogenesis of multiple sclerosis (MS) is controversial. We investigated the expression of B-cell-activating factor of the tumor necrosis factor family (BAFF), a protein indispensable for B-cell survival, and of its three receptors in MS patients and controls. BAFF mRNA levels in monocytes, and BAFF-receptor mRNA in B and T cells, were higher in patients than in healthy controls; yet, BAFF protein levels in cerebrospinal fluid and plasma were similar in patients and headache controls. In addition, each MS disease course was associated with a unique expression pattern for all four molecules. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：183 / 190
页数：8
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