Synthesis and structural characterization of a vanadium(V)- pyridylbenzimidazole complex: DNA binding and anticancer activity

被引：31
|
作者：
Mal, Sunit Kumar [1 ]
Chattopadhyay, Taraknath [1 ]
Fathima, Aafreen [2 ]
Purohit, Chandra Shekhar [3 ]
Kiran, Manikantan Syamala [4 ]
Nair, Balachandran Unni [2 ]
Ghosh, Rajarshi [1 ]
机构：
[1] Univ Burdwan, Dept Chem, Burdwan 713104, W Bengal, India
[2] CSIR Cent Leather Res Inst, Chem Lab, Chennai 600020, Tamil Nadu, India
[3] Natl Inst Sci Educ & Res, Dept Chem Sci, Bhubaneswar 751005, Orissa, India
[4] CSIR Cent Leather Res Inst, Biol Mat Lab, Chennai 600020, Tamil Nadu, India
来源：
POLYHEDRON | 2017年 / 126卷
关键词：
Vanadium; Pyridylbenzimidazole; Crystal structure; DNA binding; Cytotoxicity; SCHIFF-BASE COMPLEX; CRYSTAL-STRUCTURE; COPPER(II) COMPLEX; LIGAND; CLEAVAGE; LIGHT; 1,10-PHENANTHROLINE; REACTIVITY; DESIGN; AGENT;
D O I：
10.1016/j.poly.2017.01.008
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Synthesis and structural characterization of a new pyridylimidazole based vanadyl compound [VO2(L) (L-)] (1) [L = 2-(2-pyridyl)benzimidazole] (1) are reported. It crystallizes in Pi space group. The molecular geometry of 1 around vanadium(V) is found to be distorted octahedron. 1 interacts with DNA in a intercalative fashion. Hypochromism of the absorption band of the complex with increasing concentration of DNA and the steady increase in DNA viscosity with increasing concentration of 1 indicates intercalative mode of binding. The binding constant is calculated as 2.76 x 10(5)M(-1). 1 also shows cytotoxicity against human breast cancer, human lung cancer and human keratinocyte cancer cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：23 / 27
页数：5
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