Single-nucleotide polymorphism in the E-cadherin gene promoter modifies the risk of prostate cancer

被引：56
|
作者：
Verhage, BAJ
van Houwelingen, K
Ruijter, TEG
Kiemeney, LA
Schalken, JA
机构：
[1] Univ Nijmegen, Med Ctr, Dept Epidemiol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen, Med Ctr, Dept Urol, NL-6500 HB Nijmegen, Netherlands
[3] Univ Nijmegen, Med Ctr, Dept Pathol, NL-6500 HB Nijmegen, Netherlands
来源：
INTERNATIONAL JOURNAL OF CANCER | 2002年 / 100卷 / 06期
关键词：
prostate cancer; E-cadherin; promoter; single-nucleotide polymorphism; hereditary;
D O I：
10.1002/ijc.10541
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
E-cadherin plays a major role in intercellular adhesion, cell polarity and tissue architecture. We determined the relative risk of PCa associated with a previously reported C/A SN P at -160 bp relative to the transcription-start site of the E-cadherin gene promoter. Eighty-two PCa patients and 188 controls were genotyped. Genotype and allele frequencies differed significantly among cases and controls. A-allele carriers had a higher relative risk of PCa (OR = 3.6, 95% CI 2.0-6.4) compared to C-only carriers. AC and AA genotypes had an increased risk of PCa (OR = 3.8, 95% CI 2.1-6.8 and OR = 1.7, 95% CI 0.4-6.6, respectively) compared to CC genotypes. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码：683 / 685
页数：3
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