The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides

被引：23

作者：

Zhang, Nan ^{[1
,2
]}

Tan, Chunyan ^{[1
]}

Cai, Puqin ^{[1
]}

Zhang, Peizhuo ^{[3
]}

Zhao, Yufen ^{[2
]}

Jiang, Yuyang ^{[1
,4
]}

机构：

[1] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China

[2] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[3] Shanghai GenePharma Co Ltd, Shanghai 201203, Peoples R China

[4] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 22期

关键词：

PRODRUGS;

D O I：

10.1039/b903331a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hypoxia-activated pro-oligonucleotides were synthesized through the commercial phosphoramidite method, and could be readily cleaved to form normal oligos with good hypoxia selectivity in vitro under the effect of reductases, as well as in tumor cell extract.

引用

页码：3216 / 3218

页数：3

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