Pileamartines A and B: Alkaloids from Pilea aff. martinii with a new carbon skeleton

被引：5

作者：

Ai Doan Thi Thuy ^{[1
,2
,3
]}

Van Trinh Thi Thanh ^{[1
]}

Huong Doan Thi Mai ^{[1
]}

Huyen Tram Le ^{[3
]}

Litaudon, Marc ^{[4
]}

Van Minh Chau ^{[1
]}

Van Cuong Pham ^{[1
]}

机构：

[1] VAST, Inst Marine Biochem, Adv Ctr Bioorgan Chem, 18 Hoang Quoc Viet Rd, VAST, Vietnam

[2] Natl Univ Agr, Hanoi, Vietnam

[3] HUST, 1 Dai Co Viet, Hanoi, Vietnam

[4] Univ Paris Satiny, Inst Chim Subst Nat, CNRS ICSN, UPR 2301, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 20期

关键词：

Pileamartine; Alkaloid; Pilea; Urticaceae; Indolizidine; CAVALERIEI;

D O I：

10.1016/j.tetlet.2018.03.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel alkaloids, with an unprecedented carbon skeleton, pileamartines A (1) and B (2), together with the known alkaloid, julandine (I-a) were isolated from the alkaloidal fraction of Pilea aff. martinii leaves. Their structures were established by spectral data analysis, including MS and 2D NMR. The absolute configurations of 1 and 2 were suggested by comparison of their experimental and calculated electronic circular dichroism spectra. Compound 2 exhibited weak inhibitory activity against the a-glucosidase enzyme with an inhibition of 11% at a concentration of 200 mu M. These compounds were not cytotoxic against several cancer cell lines even at a concentration of 150 mu M. (C) 2018 Published by Elsevier Ltd.

引用

页码：1909 / 1912

页数：4

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