Cobalt-Catalyzed Reductive Alkylation of Amines with Carboxylic Acids

被引：21
|
作者：
Emayavaramban, Balakumar [1 ]
Chakraborty, Priyanka [1 ]
Sundararaju, Basker [1 ]
机构：
[1] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India
来源：
CHEMSUSCHEM | 2019年 / 12卷 / 13期
关键词：
alkylation; amines; carboxylic acids; cobalt; reduction; C-H ALKYLATION; N-ALKYLATION; SODIUM-BOROHYDRIDE; COOPERATIVE CATALYSIS; SECONDARY-AMINES; AROMATIC-AMINES; BRONSTED ACID; HYDROGENATION; AMINATION; MILD;
D O I：
10.1002/cssc.201802144
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Direct reductive alkylation of amines with carboxylic acid is carried out by using an inexpensive, air-stable cobalt/triphos catalytic system with molecular hydrogen as the reductant. This efficient synthetic method proceeds through reduction and condensation, followed by reduction of the in situ-generated imine into the amine in a green catalytic process.
引用
收藏
页码：3089 / 3093
页数：5
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