EML4-ALK: Honing In on a New Target in Non-Small-Cell Lung Cancer

被引:249
|
作者
Horn, Leora [1 ]
Pao, William [1 ]
机构
[1] Vanderbilt Ingram Canc Ctr, Nashville, TN USA
关键词
GROWTH-FACTOR RECEPTOR; ACTIVATING MUTATIONS; FUSION GENE; ALK KINASE; KRAS MUTATIONS; NEVER SMOKERS; PHASE-III; NPM-ALK; GEFITINIB; IDENTIFICATION;
D O I
10.1200/JCO.2009.23.6661
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:4232 / 4235
页数:4
相关论文
共 50 条
  • [41] Malignant pleural effusion cell blocks are substitutes for tissue in EML4-ALK rearrangement detection in patients with advanced non-small-cell lung cancer
    Zhong, J.
    Li, X.
    Bai, H.
    Zhao, J.
    Wang, Z.
    Duan, J.
    An, T.
    Wu, M.
    Wang, Y.
    Wang, S.
    Wang, J.
    CYTOPATHOLOGY, 2016, 27 (06) : 433 - 443
  • [42] Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells
    Wang, Rui
    Deng, Xiaolan
    Yoshioka, Yuichiro
    Vougiouklakis, Theodore
    Park, Jae-Hyun
    Suzuki, Takehiro
    Dohmae, Naoshi
    Ueda, Koji
    Hamamoto, Ryuji
    Nakamura, Yusuke
    CANCER SCIENCE, 2017, 108 (06) : 1203 - 1209
  • [43] Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
    Manabu Soda
    Young Lim Choi
    Munehiro Enomoto
    Shuji Takada
    Yoshihiro Yamashita
    Shunpei Ishikawa
    Shin-ichiro Fujiwara
    Hideki Watanabe
    Kentaro Kurashina
    Hisashi Hatanaka
    Masashi Bando
    Shoji Ohno
    Yuichi Ishikawa
    Hiroyuki Aburatani
    Toshiro Niki
    Yasunori Sohara
    Yukihiko Sugiyama
    Hiroyuki Mano
    Nature, 2007, 448 : 561 - 566
  • [44] Clinicopathologic Features of Non-Small-Cell Lung Cancer with EML4–ALK Fusion Gene
    Tsuyoshi Takahashi
    Makoto Sonobe
    Masashi Kobayashi
    Akihiko Yoshizawa
    Toshi Menju
    Ei Nakayama
    Nobuya Mino
    Shotaro Iwakiri
    Kiyoshi Sato
    Ryo Miyahara
    Kenichi Okubo
    Toshiaki Manabe
    Hiroshi Date
    Annals of Surgical Oncology, 2010, 17 : 889 - 897
  • [45] Clinicopathological Characteristics of Patients with Non-Small-Cell Lung Cancer Who Harbor EML4-ALK Fusion Gene: A Meta-Analysis
    Zhao, Fengzhi
    Xu, Meng
    Lei, Honcho
    Zhou, Ziqi
    Wang, Liang
    Li, Ping
    Zhao, Jianfu
    Hu, Penghui
    PLOS ONE, 2015, 10 (02):
  • [46] EML4-ALK Fusion in Lung
    Mano, Hiroyuki
    Takeuchi, Kengo
    AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (03): : 1552 - 1553
  • [47] Evaluation of EML4-ALK Fusion Proteins in Non-Small Cell Lung Cancer Using Small Molecule Inhibitors
    Li, Yongjun
    Ye, Xiaofen
    Liu, Jinfeng
    Zha, Jiping
    Pei, Lin
    NEOPLASIA, 2011, 13 (01): : 1 - U14
  • [48] EMT is associated with, but does not drive resistance to ALK inhibitors among EML4-ALK non-small cell lung cancer
    Gower, Arjan
    Hsu, Wei-Hsun
    Hsu, Shuo-Tse
    Wang, Yisong
    Giaccone, Giuseppe
    MOLECULAR ONCOLOGY, 2016, 10 (04) : 601 - 609
  • [49] Non-small Cell Lung Cancer Patients with EML4-ALK Fusion Gene Are Insensitive to Cytotoxic Chemotherapy
    Morodomi, Yosuke
    Takenoyama, Mitsuhiro
    Inamasu, Eiko
    Toyozawa, Ryo
    Kojo, Miyako
    Toyokawa, Gouji
    Shiraishi, Yoshimasa
    Takenaka, Tomoyoshi
    Hirai, Fumihiko
    Yamaguchi, Masafumi
    Taguchi, Kenichi
    Seto, Takashi
    Sugio, Kenji
    Ichinose, Yukito
    ANTICANCER RESEARCH, 2014, 34 (07) : 3825 - 3830
  • [50] Prognostic versus predictive value of EML4-ALK translocation in metastatic non-small cell lung cancer
    Shaw, A. T.
    Yeap, B.
    Costa, D. B.
    Solomon, B. J.
    Kwak, E. L.
    Nguyen, A. T.
    Bergethon, K.
    Engelman, J. A.
    Iafrate, A. J.
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)