Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury

被引:37
|
作者
Diniz, Lucio Ricardo Leite [1 ]
Souza, Marilia Trindade de Santana [2 ]
Duarte, Allana Brunna Sucupira [3 ]
Sousa, Damiao Pergentino de [3 ]
机构
[1] Coll Nordeste Bahia, Dept Nursing, BR-48590000 Coronel Joao Sa, BA, Brazil
[2] Uninassau Univ, Ctr Pharm, BR-49075479 Aracaju, SE, Brazil
[3] Univ Fed Paraiba, Dept Pharmaceut Sci, BR-58051970 Joao Pessoa, PB, Brazil
来源
MOLECULES | 2020年 / 25卷 / 23期
关键词
natural products; medicinal plants; flavonoids; antioxidant; anti-inflammatory activity; nephroprotective activity; renoprotective activity; SARS-CoV; Middle East respiratory syndrome virus; coronavirus; NF-KAPPA-B; RENAL ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; VIRUS-INFECTION; ANTIOXIDANT PROPERTIES; HEPATITIS-B; RATS; AKI; ACTIVATION; GLOMERULONEPHRITIS;
D O I
10.3390/molecules25235772
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients.
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收藏
页数:19
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