The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients.
机构:
Med Univ Graz, Dept Internal Med, Div Angiol, Graz, AustriaMed Univ Graz, Dept Internal Med, Div Angiol, Graz, Austria
Greistorfer, Thiemo
Jud, Philipp
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Med Univ Graz, Dept Internal Med, Div Angiol, Graz, Austria
Med Univ Graz, Dept Internal Med, Div Angiol, Auenbruggerpl 15, A-8036 Graz, AustriaMed Univ Graz, Dept Internal Med, Div Angiol, Graz, Austria
机构:
Emory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Truong, Alexander D.
Auld, Sara C.
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Emory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Auld, Sara C.
Barker, Nicholas A.
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Emory St Josephs Hosp, Dept Pharm, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Barker, Nicholas A.
Friend, Sarah
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Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Friend, Sarah
Wynn, A. Thanushi
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Emory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Wynn, A. Thanushi
Cobb, Jason
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Emory Univ, Sch Med, Dept Med, Div Renal Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Cobb, Jason
Sniecinski, Roman M.
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Emory Univ, Sch Med, Dept Anesthesiol, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Sniecinski, Roman M.
Tanksley, Christin-Lauren
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Emory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Tanksley, Christin-Lauren
Polly, Derek M.
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Emory Univ Hosp Midtown, Dept Pharm, Atlanta, GA USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Polly, Derek M.
Gaddh, Manila
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Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Gaddh, Manila
Connor, Michael
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Emory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Connor, Michael
Nakahara, Hirotomo
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Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Nakahara, Hirotomo
Sullivan, H. Clifford
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Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Sullivan, H. Clifford
Kempton, Christine
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Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Kempton, Christine
Guarner, Jeannette
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Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Guarner, Jeannette
Duncan, Alexander
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Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Duncan, Alexander
Josephson, Cassandra D.
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Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Josephson, Cassandra D.
Roback, John D.
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Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Roback, John D.
Stowell, Sean R.
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Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
Stowell, Sean R.
Maier, Cheryl L.
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Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Med, Emory Crit Care Ctr,Div Pulm Allergy Crit Care &, Atlanta, GA 30322 USA
机构:
Univ Belgrade, Fac Med, Beograd, Serbia
Univ Hosp Ctr Dr Dragisa Misovic, Nephrol & Hemodialysis, Beograd, SerbiaUniv Belgrade, Fac Med, Beograd, Serbia
Trbojevic-Stankovic, Jasna
Marjanovic, Zoran
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Univ Hosp Ctr Dr Dragisa Misovic, Nephrol & Hemodialysis, Beograd, SerbiaUniv Belgrade, Fac Med, Beograd, Serbia