The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients.
机构:
Univ Calif San Francisco, Div Crit Care Med, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
Invest Network Initiat Cardiovasc & Renal Clinica, Nancy, FranceUniv Calif San Francisco, Div Crit Care Med, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
Legrand, Matthieu
Bell, Samira
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Univ Dundee, Sch Med, Div Populat Hlth & Genom, Dundee, ScotlandUniv Calif San Francisco, Div Crit Care Med, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
Bell, Samira
Forni, Lui
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Royal Surrey Hosp NHS Fdn Trust, Intens Care Unit, Surrey, England
Univ Surrey, Fac Hlth Sci, Dept Clin & Expt Med, Surrey, EnglandUniv Calif San Francisco, Div Crit Care Med, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
Forni, Lui
Joannidis, Michael
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Med Univ Innsbruck, Div Intens Care & Emergency Med, Innsbruck, AustriaUniv Calif San Francisco, Div Crit Care Med, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
Joannidis, Michael
Koyner, Jay L.
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Univ Chicago, Dept Med, Div Nephrol, 5841 S Maryland Ave, Chicago, IL 60637 USAUniv Calif San Francisco, Div Crit Care Med, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
Koyner, Jay L.
Liu, Kathleen
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机构:
Univ San Francisco, Dept Med, Div Nephrol, San Francisco, CA USA
Univ San Francisco, Dept Med, Div Crit Care Med, San Francisco, CA USA
Univ San Francisco, Dept Anesthesia, Div Nephrol, San Francisco, CA USA
Univ San Francisco, Dept Anesthesia, Div Crit Care Med, San Francisco, CA USAUniv Calif San Francisco, Div Crit Care Med, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
Liu, Kathleen
Cantaluppi, Vincenzo
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Univ Piemonte Orientate, Dept Translat Med, Nephrol & Kidney Transplantat Unit, Novara, ItalyUniv Calif San Francisco, Div Crit Care Med, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
机构:
Northwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USA
Northwell Health, Donald & Barbara Zucker Sch Med, Glomerular Ctr Northwell Hlth, Hofstra Northwell, New Hyde Pk, NY 11040 USANorthwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USA
Sharma, Purva
Ng, Jia H.
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Northwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USANorthwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USA
Ng, Jia H.
Bijol, Vanesa
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Northwell Health, Donald & Barbara Zucker Sch Med, Glomerular Ctr Northwell Hlth, Hofstra Northwell, New Hyde Pk, NY 11040 USA
Northwell Health, Dept Pathol, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY USANorthwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USA
Bijol, Vanesa
Jhaveri, Kenar D.
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Northwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USA
Northwell Health, Donald & Barbara Zucker Sch Med, Glomerular Ctr Northwell Hlth, Hofstra Northwell, New Hyde Pk, NY 11040 USANorthwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USA
Jhaveri, Kenar D.
Wanchoo, Rimda
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Northwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USA
Northwell Health, Donald & Barbara Zucker Sch Med, Glomerular Ctr Northwell Hlth, Hofstra Northwell, New Hyde Pk, NY 11040 USANorthwell Health, Div Kidney Dis & Hypertens, Donald & Barbara Zucker Sch Med, Hofstra Northwell, New Hyde Pk, NY 11040 USA
机构:
Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yale Univ, Dept Internal Med, Sch Med, Sect Nephrol, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Aklilu, Abinet M.
Kumar, Sanchit
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Kumar, Sanchit
Nugent, James
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yale Univ, Sch Med, Dept Pediat, Sect Nephrol, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Nugent, James
Yamamoto, Yu
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yamamoto, Yu
Coronel-Moreno, Claudia
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Coronel-Moreno, Claudia
Kadhim, Bashar
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yale Univ, Sch Med, Dept Internal Med, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Kadhim, Bashar
Faulkner, Sophia C.
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Faulkner, Sophia C.
O'Connor, Kyle D.
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
O'Connor, Kyle D.
Yasmin, Farah
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yasmin, Farah
Greenberg, Jason H.
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yale Univ, Sch Med, Dept Pediat, Sect Nephrol, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Greenberg, Jason H.
Moledina, Dennis G.
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yale Univ, Dept Internal Med, Sch Med, Sect Nephrol, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Moledina, Dennis G.
Testani, Jeffrey M.
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yale Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Testani, Jeffrey M.
Wilson, F. Perry
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Yale Univ, Clin & Translat Res Accelerator, New Haven, CT USA
Yale Univ, Dept Internal Med, Sch Med, Sect Nephrol, New Haven, CT USAYale Univ, Clin & Translat Res Accelerator, New Haven, CT USA