Differences in performance in CAMCOG-R domains between old and oldest old patients with Alzheimer's disease

The purpose of this study is to evaluate the neuropsychological performance in a 90-year-old population with Alzheimer disease (AD) in comparison with younger elderly patients. We retrospectively studied all patients with AD attended in a specialized clinic between 1999 and 2011. Age, sex, educational level, and sensory loss data were collected. Neuropsychological evaluation included Mini-Mental State Examination and Global Deterioration Scale. We used the eight Cambridge Cognitive Assessment (CAMCOG-R) domains to evaluate and compare the neuropsychological performance in the younger than 90years old (<90) and older than 90years old (90) groups. We selected 2931 patients, 2897 <90 (98.83%) and 34 90years old (1.17%). The 90 group had significant lower punctuations in memory, praxis, and abstract thinking CAMOCG-R domains with 1.49, 0.75, and 0.58 less points, respectively, (p<0.05). Neuropsychological characteristics of cognitive decline seem to be different in 90 compared to <90years old patients. According to age, the biggest differences in the CAMCOG-R performance are in the memory, praxis, and abstract thinking domains.