Synthesis of chiral oxazolidinone derivatives through lipase-catalyzed kinetic resolution

被引：15

作者：

Zhang, Yan ^{[1
]}

Zhang, Yang ^{[1
]}

Ren, Yansong ^{[1
]}

Ramstrom, Olof ^{[1
]}

机构：

[1] KTH Royal Inst Technol, Dept Chem, S-10044 Stockholm, Sweden

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2015年 / 122卷

关键词：

Lipases; Kinetic resolution; Oxazolidinone; Asymmetric synthesis; EFFICIENT ASYMMETRIC-SYNTHESIS; ANTIBACTERIAL AGENTS; 1,3-OXATHIOLAN-5-ONE DERIVATIVES; RECYCLABLE CATALYST; SYSTEMIC RESOLUTION; ALPHA; PROMISCUITY; 3-ARYL-2-OXOOXAZOLIDINES; 3-ARYL-2-OXAZOLIDINONES; CYCLOADDITION;

D O I：

10.1016/j.molcatb.2015.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of enantioenriched oxazolidinone derivatives through lipase-catalyzed kinetic resolution is described. The synthesis comprised a two-step, cascade acylation in one pot, resulting in a range of oxazolidinone derivatives in good yields and excellent enantiopurities. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：29 / 34

页数：6

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