Lipase-catalyzed asymmetric synthesis of oxathiazinanones through dynamic covalent kinetic resolution

被引：15
|
作者：
Hu, Lei [1 ]
Zhang, Yan [1 ]
Ramstrom, Olof [1 ]
机构：
[1] Royal Inst Technol, Dept Chem, Stockholm, Sweden
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 22期
基金：
瑞典研究理事会;
关键词：
TRANSFORMATION; TEMPERATURE; LIBRARY; ENZYMES; SCALE;
D O I：
10.1039/c4ob00365a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A domino addition-lactonization pathway has been applied to a dynamic covalent resolution protocol, leading to efficient oxathiazinanone formation as well as chiral discrimination. A new, double biocatalytic pathway has furthermore been proposed and evaluated where the initial product inhibition could be efficiently circumvented.
引用
收藏
页码：3572 / 3575
页数：4
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