Imaging depth extension of optical coherence tomography by optical clearing method in vitro rabbit eye

被引：0

作者：

Kong, Ruiming ^{[1
]}

Wu, Wenjuan ^{[1
]}

Zhao, Hongwei ^{[1
]}

Qiu, Rui ^{[1
]}

Li, Guoqiang ^{[2
]}

Liu, Ailin ^{[3
]}

Lu, Xinmin ^{[4
]}

Dai, Cuixia ^{[1
]}

机构：

[1] Shanghai Inst Technol, Coll Sci, Shanghai 201418, Peoples R China

[2] Ohio State Univ, Dept Ophthalmol & Visual Sci, Columbus, OH 43212 USA

[3] Fudan Univ, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China

[4] Shanghai Sixth Peoples Hosp, Shanghai 200000, Peoples R China

来源：

OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS IX | 2020年 / 11190卷

关键词：

FD-OCT; TOC; imaging depth extension; rabbit; VIVO;

D O I：

10.1117/12.2537551

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Optical coherence tomography (OCT) is a noninvasive, non-contact imaging technique, which is an indispensable diagnostic tool in ophthalmology. However, light attenuation in opaque tissues of the eye limits the imaging depth of OCT. In this study, the imaging depth of rabbit eye in vitro was extended by reduction of multiple scattering by using tissue optical clearing (TOC) agents. Results showed that with the application of glycerol in anterior segment, boundaries of ciliary muscle could be obviously differentiated. For posterior segment, the retina, the choroid, the sclera and even the eye container were also clearly imaged. All the physiology change by glycerol was recovered by a direct wash of saline in a short time.

引用

页数：7

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