Enantioselective synthesis of pseudotripeptides incorporating a γ-methylene derivative of 2,6-diaminopimelic acid:: Part 6

被引：13

作者：

Balducci, D ^{[1
]}

Porzi, G ^{[1
]}

Sandri, S ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 07期

关键词：

D O I：

10.1016/j.tetasy.2004.02.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient enantioselective synthesis of pseudotripeptides 5, 8a-d and 13a and b incorporating a 2,6-diamino-4-methylene-1,7-heptandioic acid residue, has been accomplished starting from the glycine derived chiral synthon 1 (from L-valine). The absolute configuration of the new stereocentres was assigned on the basis of H-1 NMR spectra. The geometry of derivative 4 was deduced on the basis of H-1 NMR parameters (delta(NH) value, temperature coefficient, delta(NH) change upon addition of DMSO or CD3OD, NOE studies) and IR spectra. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1085 / 1093

页数：9

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