Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

被引：0
|
作者：
Combariza, Miguel E. [1 ]
Yu, Xinghuo [1 ]
Nesbitt, Warwick [1 ,2 ]
Tovar-Lopez, Francisco [1 ]
Rabus, Dominik G. [1 ,3 ]
Mitchell, Arnan [1 ]
机构：
[1] RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic, Australia
[2] Monash Univ, Australian Ctr Blood Dis, Melbourne, Vic 3004, Australia
[3] Burkert Fluid Control Syst, Ingelfingen, Germany
来源：
MICRO+NANO MATERIALS, DEVICES, AND SYSTEMS | 2015年 / 9668卷
关键词：
Dynamic modelling; automation; flow control; microfluidics; blood clotting; high-throughput; diagnostics; PLATELET THROMBUS FORMATION; FLOW-CHAMBER SYSTEM; ON-A-CHIP; IDENTIFICATION; AGGREGATION; DEVICES; MICROCHANNELS; EXERCISE;
D O I：
10.1117/12.2202367
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.
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页数：10
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