The Chicken or the Egg: MicroRNA-Mediated Regulation of mRNA Translation or mRNA Stability

被引：23
|
作者：
Omer, Arina D. [1 ,2 ,3 ]
Janas, Maja M. [1 ,2 ,3 ]
Novina, Carl D. [1 ,2 ,3 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[3] Broad Inst MIT & Harvard, Cambridge, MA 02141 USA
来源：
MOLECULAR CELL | 2009年 / 35卷 / 06期
关键词：
CAENORHABDITIS-ELEGANS; INITIATION-FACTOR; IN-VITRO; PROTEIN; MECHANISMS; COMPLEX;
D O I：
10.1016/j.molcel.2009.09.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Molecular Cell, Fabian et al. (2009) demonstrate that in cell-free extracts from mouse Krebs-2 ascites, microRNA-mediated translational repression precedes target mRNA deadenylation, and identify GW182, PABP, and deadenylase subunits CAR and CCR4 as factors required for deadenylation.
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页码：739 / 740
页数：2
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