A Biosynthetic Numbering System for Diterpene Pyrones

被引：2
|
作者：
Al-Khdhairawi, Amjad Ayad Qatran [1 ,2 ]
Cordell, Geoffrey A. [3 ,4 ]
Weber, Jean-Frederic F. [2 ]
Nagojappa, Narendra Babu Shivanagere [1 ]
机构：
[1] Taylors Univ, Fac Hlth & Med Sci, Sch Pharm, Lakeside Campus, Subang Jaya 47500, Selangor, Malaysia
[2] Univ Teknol MARA UiTM, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia
[3] Nat Prod Inc, Evanston, IL USA
[4] Univ Florida, Coll Pharm, Dept Pharmaceut, Gainesville, FL USA
来源：
NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 07期
关键词：
diterpene pyrones; biosynthesis; systematic numbering; fungal secondary metabolites; ALKALOIDS;
D O I：
10.1177/1934578X19860366
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Diterpene pyrones, spiroditerpenoids, and brevianes are names given to a series of fungal meroterpenoids that share common structural features and a common biosynthetic pathway elaborated by multiple oxidations, rearrangements, and cyclizations to produce the observed structural diversity. A unifying approach to the numbering of these fungal metabolites, based on a common biosynthetic progenitor, a geranylgeranyl-pyrone hybrid, is presented. This proposal will foster simplicity through a standardized numbering system that can be applied to the known members of this family, as well as to future metabolites.
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收藏
页数：2
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