Urinary Biomarkers for Prostate Cancer

被引：37
|
作者：
Tosoian, Jeffrey J. [1 ]
Ross, Ashley E. [1 ]
Sokoll, Lori J. [2 ]
Partin, Alan W. [1 ]
Pavlovich, Christian P. [1 ]
机构：
[1] Johns Hopkins Med Inst, Dept Urol, James Buchanan Brady Urol Inst, Baltimore, MD 21287 USA
[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21287 USA
来源：
UROLOGIC CLINICS OF NORTH AMERICA | 2016年 / 43卷 / 01期
关键词：
LONG NONCODING RNA; COENZYME-A RACEMASE; CPG ISLAND HYPERMETHYLATION; CELL-FREE DNA; PCA3; SCORE; EXTRACELLULAR VESICLES; RADICAL PROSTATECTOMY; CIRCULATING DNA; HEALTH INDEX; BIOCHEMICAL RECURRENCE;
D O I：
10.1016/j.ucl.2015.08.003
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In light of the overdiagnosis and overtreatment associated with widespread prostate-specific antigen based screening, controversy persists surrounding the detection and diagnosis of prostate cancer (PCa). Given its anatomic proximity to the prostate, urine has been proposed as a noninvasive substrate for prostatic biomarkers. With greater understanding of the molecular pathways of carcinogenesis and significant technological advances, the breadth of potential biomarkers is substantial. In this review, the authors aim to provide an evidence-based assessment of current and emerging urinary biomarkers used in the detection and prognostication of PCa and high-grade PCa, with particular attention on clinically relevant findings.
引用
收藏
页码：17 / +
页数：23
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