Utility of Brain Natriuretic Peptide as a Predictor of Atrial Fibrillation After Cardiac Operations

被引:20
|
作者
Tavakol, Morteza
Hassan, Kashif Z.
Abdula, Raushan K.
Briggs, William
Oribabor, Charles E.
Tortolani, Anthony J.
Sacchi, Terrence J.
Lee, Leonard Y.
Heitner, John F.
机构
[1] New York Methodist Hosp, Div Cardiol, Dept Med, Dept Stat, Brooklyn, NY 11215 USA
[2] New York Methodist Hosp, Dept Cardiothorac Surg, Brooklyn, NY 11215 USA
[3] Cornell Univ, Weill Med Coll, Dept Cardiothorac Surg, New York, NY 10021 USA
来源
ANNALS OF THORACIC SURGERY | 2009年 / 88卷 / 03期
关键词
BYPASS-SURGERY; SINUS RHYTHM; STROKE; AMIODARONE; PREVENTION; REDUCTION; MARKERS; TRIAL; RISK;
D O I
10.1016/j.athoracsur.2009.04.021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Atrial fibrillation (AF) occurs frequently after coronary bypass grafting and valve operations. Brain natriuretic peptide (BNP) has been shown to predict recurrence of AF in congestive heart failure. It is a potential biomarker for preoperative risk stratification for development of AF in at-risk patients. Methods. A total of 398 consecutive patients were prospectively evaluated for new-onset AF after heart operations. Patients with a history of AF and presence of permanent pacemaker were excluded. BNP levels were measured before and immediately after the operation. Results. AF occurred in 20%. AF was more likely to develop in patients who were older, who underwent valve operations, had a lower ejection fraction, and a larger left atrial size. Preoperative exposure to statins (62% vs 43%, p < 0.01) and angiotensin inhibitors (60% vs 45%, p = 0.02) was more common in patients without AF. BNP values were insignificantly higher preoperatively ( 361 vs 302 mg/dL, p = 0.3) and postoperatively ( 312 vs. 229 mg/ dL, p = 0.15) in patients with AF. Multivariate logistic analysis showed that older age ( odds ratio [ OR], 3.1, 95% confidence interval [CI], 1.7 to 5.6), lower ejection fraction ( OR, 2.0; 95% CI, 1.2 to 3.3), larger left atrial size ( OR, 3.1; 95% CI, 1.9 to 4.9), and nonuse of angiotensin inhibitors ( OR, 2.3; 95% CI, 1.1 to 4.8) were independently associated with AF. Conclusions. This study does not support use of BNP for prediction of AF. Age, low ejection fraction, large left atrial size, and nonuse of angiotensin blocking agents were found to be significant predictors of AF development.
引用
收藏
页码:802 / 808
页数:8
相关论文
共 50 条
  • [41] Brain Natriuretic Peptide (BNP): a relevant biomarker in atrial fibrillation (AF) diagnostic strategy after stroke?
    Suissa, L.
    Lachaud, S.
    Mahagne, M. H.
    CEREBROVASCULAR DISEASES, 2013, 35 : 486 - 487
  • [42] Brain Natriuretic Peptide and Discovery of Atrial Fibrillation After Stroke A Subanalysis of the Find-AFRANDOMISED Trial
    Wasser, Katrin
    Weber-Kruger, Mark
    Groschel, Sonja
    Uphaus, Timo
    Liman, Jan
    Hamann, Gerhard F.
    Kermer, Pawel
    Seegers, Joachim
    Binder, Lutz
    Gelbrich, Goetz
    Groeschel, Klaus
    Wachter, Rolf
    STROKE, 2020, 51 (02) : 395 - 401
  • [43] Atrial natriuretic peptide before and after cardioversion therapy in patients with chronic atrial fibrillation
    Wozalkowska-Kaplon, B
    Opolski, G
    Janion, M
    EUROPEAN HEART JOURNAL, 2002, 23 : 279 - 279
  • [44] Normalization of the atrial natriuretic peptide level after successful cardioversion of chronic atrial fibrillation
    Wozakowska-Kaplon, B
    Opolski, G
    Janion, M
    EUROPEAN HEART JOURNAL, 2000, 21 : 560 - 560
  • [45] ATRIAL NATRIURETIC PEPTIDE IN ATRIAL-FIBRILLATION BEFORE AND AFTER ELECTRICAL CARDIOVERSION THERAPY
    PETERSEN, P
    KASTRUP, J
    VILHELMSEN, R
    SCHUTTEN, HJ
    EUROPEAN HEART JOURNAL, 1988, 9 (06) : 639 - 641
  • [46] Why it is necessary to prevent atrial fibrillation after cardiac operations?
    Banach, Maciej
    KARDIOCHIRURGIA I TORAKOCHIRURGIA POLSKA, 2007, 4 (04): : 346 - 349
  • [47] Left Atrial Appendage Velocity as a Predictor of Atrial Fibrillation After Cardiac Surgery
    Ngai, Jennie
    Leonard, James
    Echevarria, Ghislaine
    Neuburger, Peter
    Applebaum, Robert
    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2016, 30 (02) : 413 - 417
  • [48] Brain natriuretic peptide as a surrogate marker for cardioembolic stroke with paroxysmal atrial fibrillation
    Naya, Takayuki
    Yukiiri, Kazushi
    Hosomi, Naohisa
    Takahashi, Tsutomu
    Ohkita, Hiroyuki
    Mukai, Mao
    Koziol, James A.
    Kohno, Masakazu
    CEREBROVASCULAR DISEASES, 2008, 26 (04) : 434 - 440
  • [49] Cardioversion for chronic atrial fibrillation is associated with an immediate drop in brain natriuretic peptide
    Vinch, CS
    Rashkin, J
    Logsetty, G
    Tighe, DA
    Hill, JC
    Meyer, TE
    Rosenthal, LS
    Aurigemma, GP
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (05) : 134A - 134A
  • [50] Brain natriuretic peptide is a marker associated with thrombus in stroke patients with atrial fibrillation
    Okada, Yoko
    Shibazaki, Kensaku
    Kimura, Kazumi
    Matsumoto, Noriko
    Iguchi, Yasuyuki
    Aoki, Junya
    Kobayashi, Kazuto
    Sakai, Kennichiro
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2011, 301 (1-2) : 86 - 89