Therapeutic Plasma Exchange Improved Pregnancy-associated Thrombotic Microangiopathy but not the Pregnancy Outcome in Patient with Systemic Lupus Erythematosus

被引：0

作者：

Terasaki, Toshihiko ^{[1
]}

Kondo, Yuya ^{[1
]}

Takahashi, Mayumi ^{[1
]}

Tawara, Takashi ^{[1
]}

Fujita, Akiko ^{[1
]}

Yagi, Hiroya ^{[2
]}

Kawai, Hitomi ^{[3
]}

Noguchi, Masayuki ^{[3
]}

Sato, Ryota ^{[1
]}

Terasaki, Mayu ^{[1
]}

Okamoto, Shota ^{[1
]}

Toko, Hirofumi ^{[1
]}

Yagishita, Mizuki ^{[1
]}

Takahashi, Hiroyuki ^{[1
]}

Hagiwara, Shinya ^{[1
]}

Tsuboi, Hiroto ^{[1
]}

Matsumoto, Isao ^{[1
]}

Sumida, Takayuki ^{[1
]}

机构：

[1] Univ Tsukuba, Fac Med, Dept Internal Med, Tsukuba, Ibaraki, Japan

[2] Univ Tsukuba, Fac Med, Dept Obstet & Gynecol, Tsukuba, Ibaraki, Japan

[3] Univ Tsukuba, Inst Basic Sci, Dept Pathol, Tsukuba, Ibaraki, Japan

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 24期

关键词：

systemic lupus erythematosus; thrombotic microangiopathy; pregnancy; plasma exchange; THROMBOCYTOPENIC PURPURA;

D O I：

10.2169/internalmedicine.4655-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombotic microangiopathy (TMA) is a rare but life-threatening complication of systemic lupus erythematosus (SLE) and is associated with adverse pregnancy outcomes. We herein report a 30-year-old pregnant woman with SLE complicated by TMA. Because her condition was unresponsive to initial corticosteroid and fresh-frozen plasma infusion treatment. we attempted plasma exchange (PE). Although thrombocytopenia and microangiopathic hemolytic anemia gradually improved, fetal death was confirmed at 23 weeks of gestation. This case suggests that PE is an effective therapeutic option but might be insufficient to maintain pregnancy in patients with SLE complicated by TMA.

引用

页码：3235 / 3238

页数：4

共 50 条

[41] A systematic review of the role of eculizumab in systemic lupus erythematosus-associated thrombotic microangiopathy
Rachael D. Wright
Fariba Bannerman
Michael W. Beresford
Louise Oni
BMC Nephrology, 21
[42] Azathioprine during pregnancy in systemic lupus erythematosus patients is not associated with poor fetal outcome
Angel Saavedra, Miguel
Sanchez, Antonio
Morales, Sara
Angeles, Ulises
Javier Jara, Luis
CLINICAL RHEUMATOLOGY, 2015, 34 (07) : 1211 - 1216
[43] A systematic review of the role of eculizumab in systemic lupus erythematosus-associated thrombotic microangiopathy
Wright, Rachael D.
Bannerman, Fariba
Beresford, Michael W.
Oni, Louise
BMC NEPHROLOGY, 2020, 21 (01)
[44] Carfilzomib Associated Thrombotic Microangiopathy Initially Treated With Therapeutic Plasma Exchange
Sullivan, Matthew R.
Danilov, Alexey V.
Lansigan, Frederick
Dunbar, Nancy M.
JOURNAL OF CLINICAL APHERESIS, 2015, 30 (05) : 308 - 310
[45] PREVIOUS PREGNANCY OUTCOME IS AN IMPORTANT DETERMINANT OF SUBSEQUENT PREGNANCY OUTCOME IN WOMEN WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
RAMSEYGOLDMAN, R
KUTZER, JE
KULLER, LH
GUZICK, D
CARPENTER, AB
MEDSGER, TA
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1992, 28 (3-4): : 195 - 198
[46] Value of Pregnancy-Associated Plasma Protein-A for Predicting Adverse Pregnancy Outcome
Jafari, Razyeh Mohamad
Masihi, Sara
Barati, Mojgan
Maraghi, Elham
Sheibani, Somayeh
Sheikhvatan, Mehrdad
ARCHIVES OF IRANIAN MEDICINE, 2019, 22 (10) : 584 - 587
[47] Pregnancy-associated plasma protein A levels and pregnancy outcome an audit with outcome data of 8000 pregnancies
Maudlin, L.
Maxey, V
Evans, A.
Chipchase, A.
Smith, R.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2016, 123 : 80 - 81
[48] ACUTE RENAL-FAILURE SECONDARY TO THROMBOTIC MICROANGIOPATHY IN A PATIENT WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
CARAVACA, F
FERNANDEZALONSO, J
ARROBAS, M
CUBERO, JJ
PIZARRO, JL
SANCHEZCASADO, E
MEDICINA CLINICA, 1987, 89 (20): : 870 - 872
[49] THROMBOTIC MICROANGIOPATHY IN PATIENT WITH PATHOGENIC PLASMINOGEN MUTATION, IN THE SETTING OF ANTIPHOSPHOLIPID SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS
Bansal, Prachi
Wagner, Samuel
AMERICAN JOURNAL OF KIDNEY DISEASES, 2025, 85 (04) : S21 - S22
[50] Therapeutic Management of Evans Syndrome in a Pregnancy with Maternal Systemic Lupus Erythematosus
Nause, S. L.
Spiegler, J.
Weichert, J.
Hartge, D. R.
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE, 2015, 219 (04): : 190 - 191

← 1 2 3 4 5 →