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Breast cancer: molecular mechanisms of underlying resistance and therapeutic approaches

被引：1
|
作者：
Tufail, Muhammad [1 ]
Cui, Jia [2 ]
Wu, Changxin [1 ]
机构：
[1] Shanxi Univ, Inst Biomed Sci, Taiyuan 030006, Shanxi, Peoples R China
[2] Changzhi Med Coll, Dept Microbiol, Changzhi 046000, Shanxi, Peoples R China
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2022年 / 12卷 / 07期
关键词：
Breast cancer; intrinsic/acquired resistance; breast cancer recurrence; breast cancer metastasis; breast cancer biomarkers; combination therapies; HEDGEHOG SIGNALING PATHWAY; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-INITIATING CELLS; MULTIDRUG-RESISTANCE; DRUG-RESISTANCE; ESTROGEN-RECEPTOR; MONOCLONAL-ANTIBODY; LOCAL RECURRENCE; DOWN-REGULATION; BETA-CATENIN;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer (BC) affects over 250,000 women in the US each year. Drug-resistant cancer cells are responsible for most breast cancer fatalities. Scientists are developing novel chemotherapeutic drugs and targeted therapy combinations to overcome cancer cell resistance. Combining drugs can reduce the chances of a tumor developing resistance to treatment. Clinical research has shown that combination chemotherapy enhances or improves survival, depending on the patient's response to treatment. Combination therapy is a highly successful supplemental cancer treatment. This review sheds light on intrinsic resistance to BC drugs and the importance of combination therapy for BC treatment. In addition to recurrence and metastasis of BC, the article discussed biomarkers for BC.
引用
收藏
页码：2920 / 2949
页数：30
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