Role of Inducible Nitric Oxide Synthase in Rostral Ventrolateral Medulla in Blood Pressure Regulation in Spontaneously Hypertensive Rats

被引：21
|
作者：
Kimura, Yoshikuni [1 ]
Hirooka, Yoshitaka [1 ]
Kishi, Takuya [1 ]
Ito, Koji [1 ]
Sagara, Yoji [1 ]
Sunagawa, Kenji [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2009年 / 31卷 / 03期
关键词：
blood pressure; heart rate; brain; nitric oxide; sympathetic nervous system; OXIDATIVE STRESS; BRAIN; EXPRESSION; OVEREXPRESSION; INFLAMMATION; CONTRIBUTES;
D O I：
10.1080/10641960902822534
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nitric oxide (NO) in the brainstem modulates blood pressure (BP). Overexpression of inducible NO synthase (iNOS) in the rostral ventrolateral medulla (RVLM) increases BP in normotensive Wistar-Kyoto rats (WKY), but its role in BP regulation in spontaneously hypertensive rats (SHR) is unknown. We examined iNOS expression and the effect of iNOS inhibitors in the RVLM on BP and heart rate in SHR and WKY. iNOS levels in the RVLM were significantly higher in SHR than in WKY. Bilateral microinjection of aminoguanidine into the RVLM dose-dependently decreased BP and heart rate in SHR, but not in WKY. These findings suggest that iNOS expression in the RVLM of SHR contributes to increase BP.
引用
收藏
页码：281 / 286
页数：6
相关论文
共 50 条
  • [41] PHYSICAL (IN)ACTIVITY AND GLUTAMATE RECEPTOR ACTIVATION IN THE ROSTRAL VENTROLATERAL MEDULLA OF SPONTANEOUSLY HYPERTENSIVE RATS
    Mancini, Eric J.
    Flack-Valdez, Amanda B.
    Mueller, Patrick J.
    FASEB JOURNAL, 2009, 23
  • [42] Role of nitric oxide in the rostral ventrolateral medulla in regulation of cardiac-sympathetic excitatory reflexes
    Guo, ZL
    Nguyen, VT
    Fu, LW
    Longhurst, JC
    FASEB JOURNAL, 2005, 19 (05): : A1302 - A1302
  • [43] Nitric oxide synthase in spontaneously hypertensive rats
    Wu, CC
    Yen, MH
    JOURNAL OF BIOMEDICAL SCIENCE, 1997, 4 (05) : 249 - 255
  • [44] ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION
    BERGAMASCHI, C
    CAMPOS, RR
    SCHOR, N
    LOPES, OU
    HYPERTENSION, 1995, 26 (06) : 1117 - 1120
  • [45] Nitric oxide in rostral ventrolateral medulla regulates cardiac-sympathetic reflexes: role of synthase isoforms
    Guo, Zhi-Ling
    Tjen-A-Looi, Stephanie C.
    Fu, Liang-Wu
    Longhurst, John C.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2009, 297 (04): : H1478 - H1486
  • [46] Nitric oxide synthase activity in renal cortex and medulla of normotensive and spontaneously hypertensive rats
    Nava, E
    Llinas, MT
    Gonzalez, JD
    Salazar, FJ
    AMERICAN JOURNAL OF HYPERTENSION, 1996, 9 (12) : 1236 - 1239
  • [47] TONIC INFLUENCE OF THE CAUDAL VENTROLATERAL MEDULLA ON THE ROSTRAL VENTROLATERAL MEDULLA IN ANESTHETIZED SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE WISTAR-KYOTO RATS
    YANG, Z
    CHAN, YS
    WONG, TM
    JOURNAL OF PHYSIOLOGY-LONDON, 1995, 487P : P180 - P180
  • [48] Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress
    Kimura, Y
    Hirooka, Y
    Sagara, Y
    Ito, K
    Kishi, T
    Shimokawa, H
    Takeshita, A
    Sunagawa, K
    CIRCULATION RESEARCH, 2005, 96 (02) : 252 - 260
  • [49] Blockade of angiotensin AT1-receptors in the rostral ventrolateral medulla of spontaneously hypertensive rats reduces blood pressure and sympathetic nerve discharge
    Allen, AM
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2001, 2 : S120 - S124
  • [50] Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress
    Kimura, Y
    Hirooka, Y
    Ito, K
    Sagara, Y
    Shimokawa, H
    Takeshita, A
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2004, 11 (01): : 120 - 120
12345