Dual inhibition of EZH2 and ATM displays synergistic cytotoxicity in BRCA1-deficient breast

被引:0
|
作者
Puppe, J. [1 ]
Brambillasca, C. [2 ]
Ratz, L. [3 ]
Bartke, L. [3 ]
van de Ven, M. [2 ]
Bouwman, P. [2 ]
van Tellingen, O. [2 ]
Isensee, J. [4 ]
Hucho, T. [4 ]
van Lohuizen, M. [2 ]
Malter, W. [3 ]
Schmutzler, R. [5 ]
Mallmann, P. [3 ]
Jonkers, J. [2 ]
Reinhardt, C. [6 ]
机构
[1] Uniklin Koln, Klin & Poliklin Frauenheilkunde & Geburtshilfe, Cologne, Germany
[2] Netherlands Canc Inst, Amsterdam, Netherlands
[3] Uniklin Koln, Klin & Poliklin Frauenheilkunde, Cologne, Germany
[4] Uniklin Koln, Cologne, Germany
[5] Uniklin Koln, Zentrum Familiarer Brust & Eierstockkrebs, Cologne, Germany
[6] Uniklin Koln, Innere Med Klin 1, Cologne, Germany
关键词
D O I
10.1055/s-0040-1717869
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
P037
引用
收藏
页码:E104 / E104
页数:1
相关论文
共 50 条
  • [31] The Retinoblastoma Gene Undergoes Rearrangements in BRCA1-Deficient Basal-like Breast Cancer
    Jonsson, Goran
    Staaf, Johan
    Vallon-Christersson, Johan
    Ringner, Markus
    Gruvberger-Saal, Sofia K.
    Saal, Lao H.
    Holm, Karolina
    Hegardt, Cecilia
    Arason, Adalgeir
    Fagerholm, Rainer
    Persson, Camilla
    Grabau, Dorthe
    Johnsson, Ellinor
    Lovgren, Kristina
    Magnusson, Linda
    Heikkila, Paivi
    Agnarsson, Bjarni A.
    Johannsson, Oskar T.
    Malmstrom, Per
    Ferno, Marten
    Olsson, Hakan
    Loman, Niklas
    Nevanlinna, Heli
    Barkardottir, Rosa B.
    Borg, Ake
    CANCER RESEARCH, 2012, 72 (16) : 4028 - 4036
  • [32] Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
    Edward Curry
    Ian Green
    Nadine Chapman-Rothe
    Elham Shamsaei
    Sarah Kandil
    Fanny L Cherblanc
    Luke Payne
    Emma Bell
    Thota Ganesh
    Nitipol Srimongkolpithak
    Joachim Caron
    Fengling Li
    Anthony G. Uren
    James P. Snyder
    Masoud Vedadi
    Matthew J. Fuchter
    Robert Brown
    Clinical Epigenetics, 2015, 7
  • [33] Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
    Brown, R.
    Fuchter, M.
    Curry, E.
    Green, I.
    Kandil, S.
    Cherblanc, F.
    Payne, L.
    Chapman-Rothe, N.
    Shamsaei, E.
    Srimongkolpithak, N.
    Snyder, J.
    Vedadi, M.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : 179 - 180
  • [34] EZH2 Regulates Growth of Estrogen Receptor Negative Breast Carcinomas by Regulating BRCA1 Localization
    Gonzalez, M. E.
    Li, X.
    Toy, K.
    DuPrie, M.
    Kleer, C. G.
    LABORATORY INVESTIGATION, 2010, 90 : 386A - 386A
  • [35] Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
    Curry, Edward
    Green, Ian
    Chapman-Rothe, Nadine
    Shamsaei, Elham
    Kandil, Sarah
    Cherblanc, Fanny L.
    Payne, Luke
    Bell, Emma
    Ganesh, Thota
    Srimongkolpithak, Nitipol
    Caron, Joachim
    Li, Fengling
    Uren, Anthony G.
    Snyder, James P.
    Vedadi, Masoud
    Fuchter, Matthew J.
    Brown, Robert
    CLINICAL EPIGENETICS, 2015, 7
  • [36] BRCA1-deficient tumors demonstrate enhanced cytotoxicity and T-cell recruitment following doxil treatment
    Mantia-Smaldone, G.
    Marsh, E.
    Loomis, R.
    Orsulic, S.
    Rubin, S.
    Coukos, G.
    Adams, S.
    GYNECOLOGIC ONCOLOGY, 2011, 121 (01) : S22 - S22
  • [37] Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors
    Shinohara, Haruka
    Sawado, Rie
    Nakagawa, Makoto
    Hattori, Ayuna
    Yamagata, Kazutsune
    Tauchi, Kimiharu
    Ito, Jumpei
    Kuwahara, Yasumichi
    Okuda, Tsukasa
    Ogawa, Chitose
    Kitabayashi, Issay
    MOLECULAR THERAPY ONCOLYTICS, 2022, 27 : 14 - 25
  • [38] Dual inhibition of EZH2 and histone deacetylases for the treatment of lymphomas with epigenetic aberrations
    Mensah, Afua Adjeiwaa
    Valente, Sergio
    Matkovic, Milos
    Sartori, Giulio
    Falzarano, Chiara
    Tarantelli, Chiara
    Cascione, Luciano
    Pileri, Stefano A.
    Cavalli, Andrea
    Mai, Antonello
    Bertoni, Francesco
    CANCER RESEARCH, 2022, 82 (12)
  • [39] STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
    Wang, Qiwei
    Bergholz, Johann S.
    Ding, Liya
    Lin, Ziying
    Kabraji, Sheheryar K.
    Hughes, Melissa E.
    He, Xiadi
    Xie, Shaozhen
    Jiang, Tao
    Wang, Weihua
    Zoeller, Jason J.
    Kim, Hye-Jung
    Roberts, Thomas M.
    Konstantinopoulos, Panagiotis A.
    Matulonis, Ursula A.
    Dillon, Deborah A.
    Winer, Eric P.
    Lin, Nancy U.
    Zhao, Jean J.
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [40] PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer
    Ding, Liya
    Kim, Hye-Jung
    Wang, Qiwei
    Kearns, Michael
    Jiang, Tao
    Ohlson, Carolynn E.
    Li, Ben B.
    Xie, Shaozhen
    Liu, Joyce F.
    Stover, Elizabeth H.
    Howitt, Brooke E.
    Bronson, Roderick T.
    Lazo, Suzan
    Roberts, Thomas M.
    Freeman, Gordon J.
    Konstantinopoulos, Panagiotis A.
    Matulonis, Ursula A.
    Zhao, Jean J.
    CELL REPORTS, 2018, 25 (11): : 2972 - +