Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis

被引：13
|
作者：
Mato, Raquel [1 ]
Reyes, Efraim [1 ]
Carrillo, Luisa [1 ]
Uria, Uxue [1 ]
Prieto, Liher [1 ]
Manzano, Ruben [1 ]
Vicario, Jose L. [1 ]
机构：
[1] Univ Basque Country, Dept Organ Chem 2, POB 644, Bilbao 48080, Spain
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 86期
关键词：
MICHAEL ADDITION; ASYMMETRIC CATALYSIS; CASCADE REACTIONS; ORGANOCATALYSTS; THIOUREA; MECHANISM; MODE; UREA;
D O I：
10.1039/d0cc05981a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes and in which three contiguous stereogenic centres, one of them a tertiary alcohol moiety, have been formed in a fully stereocontrolled fashion.
引用
收藏
页码：13149 / 13152
页数：4
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