Catalytic enantioselective domino oxa-Michael/aldol condensations:: Asymmetric synthesis of benzopyran derivatives

被引：0

作者：

Sunden, Henrik

Ibrahem, Ismail

Zhao, Gui-Ling

Eriksson, Lars

Cordova, Armando ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

[2] Stockholm Univ, Arrhenius Lab, Dept Struct Chem, S-10691 Stockholm, Sweden

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2007年 / 13卷 / 02期

关键词：

asymmetric catalysis; diphenylprolinol; domino reactions; heterocycles; oxa-Michael reaction;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first direct organocatalytic asymmetric domino oxa-Michael/aldol condensation reaction is presented. The unprecedentedly simple, chiral, pyrrolidine-catalyzed asymmetric domino reactions between salicylic aldehyde derivatives and alpha,beta-unsaturated aldehydes proceed with high chemo- and enantioselectivities to give the corresponding chromene-3-carbaldehyde derivatives in high yields and with ee values of 83-98 %.

引用

页码：574 / 581

页数：8

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