Neuropathology and pathophysiology of Parkinson's disease: Focus on α-synuclein

被引：2
|
作者：
Prigent, Alice [1 ]
Lionnet, Arthur [2 ]
Corbille, Anne-Gaelle [1 ,2 ,3 ]
Derkinderen, Pascal [1 ,2 ,3 ]
机构：
[1] INSERM, U913, F-44035 Nantes, France
[2] CHU Nantes, Serv Neurol, Blvd Jacques Monod, F-44093 Nantes 01, France
[3] Univ Nantes, F-44035 Nantes, France
来源：
PRESSE MEDICALE | 2017年 / 46卷 / 02期
关键词：
LEWY BODIES; PATHOLOGY;
D O I：
10.1016/j.lpm.2016.11.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The past 20 years has witnessed tremendous progress in our understanding of Parkinson's disease. It is now well established that alpha-synuclein, a presynaptic neuronal protein, is not only a marker but also an actor of the disease. In this review, we discuss the advances that have been obtained in neuropathology using alpha-synuclein immunohistochemistry and the role of this protein in the spread of the disease.
引用
收藏
页码：182 / 186
页数：5
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