Neuropathology and pathophysiology of Parkinson's disease: Focus on α-synuclein

被引：2
|
作者：
Prigent, Alice [1 ]
Lionnet, Arthur [2 ]
Corbille, Anne-Gaelle [1 ,2 ,3 ]
Derkinderen, Pascal [1 ,2 ,3 ]
机构：
[1] INSERM, U913, F-44035 Nantes, France
[2] CHU Nantes, Serv Neurol, Blvd Jacques Monod, F-44093 Nantes 01, France
[3] Univ Nantes, F-44035 Nantes, France
来源：
PRESSE MEDICALE | 2017年 / 46卷 / 02期
关键词：
LEWY BODIES; PATHOLOGY;
D O I：
10.1016/j.lpm.2016.11.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The past 20 years has witnessed tremendous progress in our understanding of Parkinson's disease. It is now well established that alpha-synuclein, a presynaptic neuronal protein, is not only a marker but also an actor of the disease. In this review, we discuss the advances that have been obtained in neuropathology using alpha-synuclein immunohistochemistry and the role of this protein in the spread of the disease.
引用
收藏
页码：182 / 186
页数：5
相关论文
共 50 条
  • [1] Neuropathology of α-synuclein in Parkinson's disease
    Choong, Chi-Jing
    Mochizuki, Hideki
    [J]. NEUROPATHOLOGY, 2022, 42 (02) : 93 - 103
  • [2] Neuropathology The aαsynuclein, central to Parkinson's disease
    Vernet, Agnes
    [J]. BIOFUTUR, 2012, (338) : 8 - 8
  • [3] BLENX MODELS OF α-SYNUCLEIN AND PARKIN KINETICS IN NEUROPATHOLOGY OF PARKINSON'S DISEASE
    Lecca, Paola
    [J]. JOURNAL OF BIOLOGICAL SYSTEMS, 2011, 19 (02) : 149 - 181
  • [4] Neuropathology of conditional alpha-synuclein transgenic mouse models of Parkinson's disease
    Nuber, S.
    Petrasch-Parwez, E.
    Winner, B.
    Winkler, J.
    von Hoersten, S.
    Teismann, P.
    Schulz, J. B.
    Neumann, M.
    Fendt, M.
    Gellerich, F. N.
    Riess, O.
    [J]. PARKINSONISM & RELATED DISORDERS, 2007, 13 : S122 - S122
  • [5] Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson's disease
    Niu, Xiao-yun
    Xie, Xi-xiu
    Tuo, Hou-zhen
    Lv, Cui-ping
    Huang, Ya-ru
    Zhu, Jie
    Liang, Shi-yu
    Du, Xiao-yu
    Yang, Cheng-gang
    Hou, Sheng-jie
    Sun, Xiao-ying
    Li, Ling-jie
    Cui, Fang
    Huang, Qi-xin
    Jia, Ying-bo
    Wang, Yu-jiong
    Liu, Rui-tian
    [J]. CELL DEATH DISCOVERY, 2024, 10 (01)
  • [6] Neuropathology of α-synuclein and synphilin-1 transgenic mouse models of Parkinson's disease
    Nuber, S.
    Petrasch-Parwez, E.
    Franck, T.
    Schumann, U.
    Winner, B.
    Winkler, J.
    Wolburg, H.
    Hoersten, S. V.
    Schmidt, T.
    Boy, J.
    Nguyen, H.
    Teismann, P.
    Schulz, J. B.
    Neumann, M.
    Pichler, B. J.
    Fischer, K.
    Holzmann, C.
    Schmitt, I.
    Bornemann, A.
    Kuhn, W.
    Zimmermann, F.
    Servadio, A.
    Riess, O.
    [J]. JOURNAL OF NEURAL TRANSMISSION, 2009, 116 (02) : 222 - 222
  • [7] Neuropathology of conditional alpha-synuclein transgenic mouse models of Parkinson's disease
    Nuber, S.
    Petrasch-Parwez, E.
    Winner, B.
    Winkler, J.
    von Hoersten, S.
    Teismann, P.
    Schulz, J. B.
    Neumann, M.
    Fendt, M.
    Gellerich, F. N.
    Riess, O.
    [J]. PARKINSONISM & RELATED DISORDERS, 2007, 13 : S90 - S90
  • [8] Neuropathology of Parkinson's disease
    Forno, LS
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (03): : 259 - 272
  • [9] Pathophysiology of Parkinson's disease: Mitochondria, alpha-synuclein and much more ...
    Rouaud, T.
    Corbille, A-G
    Leclair-Visonneau, L.
    de Lataillade, A. de Guilhem
    Lionnet, A.
    Preterre, C.
    Damier, P.
    Derkinderen, P.
    [J]. REVUE NEUROLOGIQUE, 2021, 177 (03) : 260 - 271
  • [10] From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease
    Bellucci, Arianna
    Zaltieri, Michela
    Navarria, Laura
    Grigoletto, Jessica
    Missale, Cristina
    Spano, PierFranco
    [J]. BRAIN RESEARCH, 2012, 1476 : 183 - 202
12345