The inhibition of γ-secretase as a therapeutic approach to Alzheimer's disease

被引：26
|
作者：
Tomita, T [1 ]
Iwatsubo, T [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Neuropathol & Neurosci, Bunkyo Ku, Tokyo 1130033, Japan
来源：
DRUG NEWS & PERSPECTIVES | 2004年 / 17卷 / 05期
关键词：
D O I：
10.1358/dnp.2004.17.5.829036
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Alzheimer's disease is a dementing neurodegenerative disorder for which there is no effective treatment at present. Genetic and biological studies provide evidence that the production and deposition of amyloid-beta peptides (Abeta) contribute to the etiology of Alzheimer's disease. gamma-Secretase is the pivotal enzyme in generating the C terminus of Abeta, which determines its aggregability and speed of deposition. Drugs that regulate the production of Abeta by inhibiting gamma-secretase activity could provide an effective therapy for Alzheimer's disease, although recent studies suggest that gamma-secretase plays important roles in cellular signaling. This review focuses on studies of the gamma-secretase biology and provides the direction for developing effective and selective gamma-secretase inhibitors as drugs for the treatment of Alzheimer's disease. (C) 2004 Prous Science. All rights reserved.
引用
收藏
页码：321 / 325
页数：5
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