Tissue-resident memory T cells: local specialists in immune defence

被引：693
|
作者：
Mueller, Scott N. [1 ,2 ]
Mackay, Laura K. [1 ,2 ]
机构：
[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia
[2] Univ Melbourne, Australian Res Council Ctr Excellence Adv Mol Ima, Melbourne, Vic 3000, Australia
来源：
NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 02期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
CUTTING EDGE; PROMOTES DIFFERENTIATION; PROTECTIVE IMMUNITY; LYMPHOID ORGANS; INFLUENZA-VIRUS; E-CADHERIN; RM CELLS; EFFECTOR; SKIN; MIGRATION;
D O I：
10.1038/nri.2015.3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cells have crucial roles in protection against infection and cancer. Although the trafficking of memory T cells around the body is integral to their capacity to provide immune protection, studies have shown that specialization of some memory T cells into unique tissue-resident subsets gives the host enhanced regional immunity. In recent years, there has been considerable progress in our understanding of tissue-resident T cell development and function, revealing mechanisms for enhanced protective immunity that have the potential to influence rational vaccine design. This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlights key unanswered questions.
引用
收藏
页码：79 / 89
页数：11
相关论文
共 50 条
  • [21] Tissue-resident memory T cells in cytomegalovirus infection
    Thom, Jenny Tosca
    Oxenius, Annette
    [J]. CURRENT OPINION IN VIROLOGY, 2016, 16 : 63 - 69
  • [22] Tissue-resident memory T cells in the urogenital tract
    Loreto Parga-Vidal
    Michiel C. van Aalderen
    Regina Stark
    Klaas P. J. M. van Gisbergen
    [J]. Nature Reviews Nephrology, 2022, 18 : 209 - 223
  • [23] Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis
    Liang, Mengjie
    Wang, Xingzhou
    Cai, Daming
    Guan, Wenxian
    Shen, Xiaofei
    [J]. FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [24] Tissue-resident memory T cells and lung immunopathology
    Cheon, In Su
    Son, Young Min
    Sun, Jie
    [J]. IMMUNOLOGICAL REVIEWS, 2023, 316 (01) : 63 - 83
  • [25] Tissue-resident memory T cells in the urogenital tract
    Parga-Vidal, Loreto
    van Aalderen, Michiel C.
    Stark, Regina
    van Gisbergen, Klaas P. J. M.
    [J]. NATURE REVIEWS NEPHROLOGY, 2022, 18 (04) : 209 - 223
  • [26] Tissue-Resident Memory T Cells in Cancer Immunosurveillance
    Park, Simone L.
    Gebhardt, Thomas
    Mackay, Laura K.
    [J]. TRENDS IN IMMUNOLOGY, 2019, 40 (08) : 735 - 747
  • [27] Knowns and unknowns of tissue-resident memory T cells
    Altmann, Daniel M.
    [J]. IMMUNOLOGY, 2019, 157 (01) : 1 - 2
  • [28] Tissue-resident memory T cells in psoriasis recurrence
    Shen, Z.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (05) : S17 - S17
  • [29] The Multifaceted Role of Tissue-Resident Memory T Cells
    Christo, Susan N.
    Park, Simone L.
    Mueller, Scott N.
    Mackay, Laura K.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2024, 42 : 317 - 345
  • [30] Tissue-resident memory T cells: The key frontier in local synovitis memory of rheumatoid arthritis
    Gao, Anqi
    Zhao, Wenpeng
    Wu, Ruihe
    Su, Rui
    Jin, Ruqing
    Luo, Jing
    Gao, Chong
    Li, Xiaofeng
    Wang, Caihong
    [J]. JOURNAL OF AUTOIMMUNITY, 2022, 133
12345