2-D graphical representation of proteins based on virtual genetic code

被引:80
|
作者
Randic, M [1 ]
机构
[1] Natl Inst Chem, Ljubljana, Slovenia
[2] Drake Univ, Dept Math & Comp Sci, Des Moines, IA 50311 USA
关键词
2-D maps; virtual genetic code; graphical representation; protein map; DNA map;
D O I
10.1080/10629360410001697744
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We consider a novel 2-D graphical representation of proteins in which individual nucleic acids are represented as "spots" within a square frame distributed according to specific construction rules. The resulting "images" of proteins can not only serve to facilitate visual comparison of similarities and dissimilarities between lengthy protein sequences, but also offer a way for mathematical characterization of protein sequences, analogous to similar considerations for lengthy DNA sequences. Basically the approach is based on the concept of virtual genetic code, which is a hypothetical string of RNA nucleic acid bases, A, C, U and G, which generates reported protein sequences, without the knowledge of the actual genetic code that produces the protein.
引用
收藏
页码:147 / 157
页数:11
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