One-pot reductive amination of aldehydes and ketones with α-picoline-borane in methanol, in water, and in neat conditions

被引：248

作者：

Sato, S ^{[1
]}

Sakamoto, T ^{[1
]}

Miyazawa, E ^{[1
]}

Kikugawa, Y ^{[1
]}

机构：

[1] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan

来源：

TETRAHEDRON | 2004年 / 60卷 / 36期

关键词：

reductive amination; picoline-borane; water solvent; neat condition;

D O I：

10.1016/j.tet.2004.06.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot reductive amination of aldehydes and ketones with amines using alpha-picoline-borane as a reducing agent is described. The reaction has been carried out in Wolf, in H2O, and in neat conditions in the presence of small amounts of AcOH. This is a highly efficient and mild procedure that is applicable for a wide variety of substrates. In particular, this is the first successful demonstration that this type of reaction can be carried out in water and in neat conditions. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7899 / 7906

页数：8

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