Excretion of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126) from Rat Liver Following Oral Administration of Lactobacillus reuteri and Lactobacillus acidophilus

被引:2
|
作者
Suzuki, Takehito [1 ]
Yamazaki, Kaora [2 ]
Shinoda, Tadashi [3 ]
Shirai, Mitsuyuki [1 ]
Yoshikawa, Hiroshi [1 ]
Noguchi, Yurika [1 ]
Ito, Tetsuro [4 ]
Ishii, Yasuo [1 ]
Takizawa, Tatsuya [1 ]
Morita, Hidetoshi [1 ]
机构
[1] Azabu Univ, Sch Vet Med, Chuo Ku, Sagamihara, Kanagawa 2525201, Japan
[2] Tokyo Kasei Gakuin Univ, Sch Contemporary Human Life Sci, Machida, Tokyo 1940292, Japan
[3] Calpis Co Ltd, R&D Ctr, Chuo Ku, Sagamihara, Kanagawa 2520206, Japan
[4] Azabu Univ, Vet Teaching Hosp, Chuo Ku, Sagamihara, Kanagawa 2525201, Japan
关键词
PCB126; Lactobacillus reuteri; Lactobacillus acidophilus; enterohepatic circulation; BILE-SALT HYDROLASE; POLYCHLORINATED-BIPHENYLS; DIOXIN; ACIDS; DECONJUGATION; ACCUMULATION; RESISTANCE; MECHANISM; EXPOSURE; EFFLUX;
D O I
10.3136/fstr.20.821
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Oral administration of Lactobacillus reuteri CP3012 or Lactobacillus acidophilus L-92 for 60 days in rats that were previously administered 3,3',4,4',5-pentachlorobiphenyl (PCB126) orally at a dose of 100 mu g/kg of body weight resulted in a significant decrease in hepatic bioaccumulation of PCB126 ( p < 0.05), with levels of 30.7 +/- 3.7 ng/g and 92.6 +/- 25.0 ng/g of liver tissue, respectively, compared with 133.1 +/- 12.7 ng/g of liver tissue in the controls. The electron paramagnetic resonance signal level of the liver PCB126-specific g = 2.49 species in rats administered L. reuteri CP3012 decreased significantly (p < 0.05). Both the bile acid concentration in the feces and total stool output increased significantly following administration of lactobacilli ( p < 0.05); however, adsorption of PCB126 onto the bacterial cells was not observed. These results suggest that these bacteria inhibit reabsorption of PCB126 with bile acid by blocking enterohepatic circulation through absorbing and/or deconjugating the bile acids in the intestinal tract and by promoting excretion of bile acids from the body, thus reducing PCB126 accumulation in the liver.
引用
收藏
页码:821 / 828
页数:8
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