Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging

被引:161
|
作者
Kuo, Wen-Shuo [1 ,2 ,3 ]
Chen, Hua-Han [4 ]
Chen, Shih-Yao [5 ]
Chang, Chia-Yuan [3 ]
Chen, Pei-Chi [2 ,6 ]
Hou, Yung-I [2 ]
Shao, Yu-Ting [2 ,7 ]
Kao, Hui-Fang [2 ,8 ]
Hsu, Chih-Li Lilian [6 ,7 ]
Chen, Yi-Chun [9 ]
Chen, Shean-Jen [1 ,3 ]
Wu, Shang-Rung [6 ,10 ]
Wang, Jiu-Yao [2 ,6 ,7 ]
机构
[1] Natl Cheng Kung Univ, Adv Optoelect Technol Ctr, Tainan 701, Taiwan
[2] Natl Cheng Kung Univ, Allergy & Clin Immunol Res Ctr, Tainan 701, Taiwan
[3] Natl Cheng Kung Univ, Ctr Micro Nano Sci & Technol, Tainan 701, Taiwan
[4] Natl Penghu Univ Sci & Technol, Dept Food Sci, Penghu 880, Taiwan
[5] Natl Cheng Kung Univ, Dept Internal Med, Tainan 701, Taiwan
[6] Natl Cheng Kung Univ, Inst Basic Med Sci, Tainan 701, Taiwan
[7] Natl Cheng Kung Univ, Dept Microbiol & Immunol, Tainan 701, Taiwan
[8] Natl Tainan Jr Coll Nursing, Dept Nursing, Tainan 700, Taiwan
[9] Natl Cheng Kung Univ, Dept Phys, Tainan 701, Taiwan
[10] Natl Cheng Kung Univ, Inst Oral Med, Tainan 701, Taiwan
关键词
Reactive oxygen species; Photodynamic therapy; Nitrogen-doped graphene quantum dot; Antimicrobial; Photostability; Contrast probe; PHOTOSENSITIZERS; OXIDE; NANOPARTICLES; AGENT; DYES;
D O I
10.1016/j.biomaterials.2016.12.022
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm(-2)), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:185 / 194
页数:10
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